A potentially more effective treatment for HER2 mutant metastatic breast cancer
A phase II clinical trial is on its way to assess the value of poziotinib in the treatment of this devastating condition.
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Metastasis
The bone microenvironment ‘empowers’ cancer cells to become metastatic
The bone microenvironment prompts changes in breast cancer cells that help them escape treatment and become more invasive.
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The single cell and the cluster, what makes one better than the other at cancer metastasis?
Cancer metastasis is all about rogue cancer cells abandoning the original tumor and venturing through the blood in search for new breeding grounds. Sometimes, single
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CD44 variants prompt different cancer cell behaviors
Imagine fighting enemies that differ in their susceptibility to the weapon you are using against them. Some will perish, but others will survive the attack
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An integrated approach to finding new treatments for breast cancer
Unraveling the complexity of cancer biology can lead to the identification new molecules involved in breast cancer and prompt new avenues for drug development. And
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Estrogen receptor can affect resistance to endocrine therapy and metastasis in breast cancer
Resistance to therapy is common in estrogen receptor positive (ER+) breast cancer, the most common type of breast cancer, and eventual development of metastatic disease
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This is what the Warburg pathway can do for breast cancer growth
To generate energy from glucose, cells can use one of two pathways. One of them takes place in the mitochondria, energy-producing structures inside cells, and
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Device that induces a mild localized ‘fever’ could treat vascular involvement in cancer
The prognosis of a cancer patient relies significantly on the ability of the surgeon to remove all the tumor, including a cancer-free boundary, leaving what
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Out of the body and into bone-in culture: new technique tests drugs for metastatic cancer
For many cancer patients, the problem is metastasis – the dissemination of tumor cells to other organs – after the primary tumor has been eliminated.
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How breast cancer can become resistant to hormone therapy
Despite the overall success of hormone therapy, breast cancer tumors in patients with metastatic disease often fail to respond. One new mechanism that can explain
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