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estrogen receptor-positive

From The Labs

Losing neurofibromin is good news for breast cancer

March 24, 2020March 25, 2020Breast Cancer, ER-corepresor, estrogen receptor-positive, fulvestrant, MEK inhibitor, neurofibromin, Ras, Research

It is well known that neurofibromin (NF1), a tumor suppressor produced by the NF1 gene, keeps cancer growth in check by repressing the activity of

From The Labs

Estrogen receptor can affect resistance to endocrine therapy and metastasis in breast cancer

October 25, 2018October 25, 2018Breast Cancer, ESR1, estrogen receptor-positive, Metastasis, Research, resistance to endocrine therapy

Resistance to therapy is common in estrogen receptor positive (ER+) breast cancer, the most common type of breast cancer, and eventual development of metastatic disease

From The Labs

How breast cancer can become resistant to hormone therapy

January 9, 2017Breast cancer resistance, Brest cancer resistance, estrogen receptor-positive, FOXA1, IL-8, Metastasis, tamoxifen

Despite the overall success of hormone therapy, breast cancer tumors in patients with metastatic disease often fail to respond. One new mechanism that can explain

From the Labs: A closer look at tertiary lymphoid structures. Image courtesy of M. Zelazowski/ P. Castro/Baylor’s Human Tissue Acquisition & Pathology (HTAP) Core.