Image of the Month: Cancer cell clusters
The image of this month shows a cluster of breast cancer tumor cells that was found in the blood of mice bearing the tumor. Researchers
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Research
The N-terminal domain of the androgen receptor is at the heart of its action
Detailed 3-D studies reveal how the androgen receptor is put together as a functional complex that drives prostate cancer.
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PolyA-miner accurately assesses the effect of alternative polyadenylation on gene expression
PolyA-miner enables scientists to evaluate the contribution of alternative polyadenylation to gene regulation in health and disease.
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New insights into the mediators of patient recovery after CAR T cell immunotherapy
Clinical trial of novel personalized CAR T cell immunotherapy provides clues into what mediated exceptional patient recovery.
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These 300,000 cells can improve our understanding of chronic lung disease
Despite substantial progress in the understandig of pulmonary fibrosis (PF) in laboratory animals, researchers have a limited perspective of the cellular and molecular processes that
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Sorting out cell type-specific molecular barcodes
In the last 10 years, scientists generated thousands of whole genome bisulfite sequencing (WGBS) data sets costing millions of dollars, yet were unable to appreciate
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No NELL2, no sperm motility. Novel protein is essential for male fertility
Newly produced spermatozoa within the testis are not fully functional until they mature in the epididymis, a duct that helps to transport and store sperm.
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Metabolomics meets genomics to improve patient diagnosis
A patient and family walk into a doctor’s office. They hope that the latest laboratory tests will reveal what is causing the patient’s illness and
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Image of the Month: Locating molecular players in Batten disease
Mutations in either protein CLN6 or CLN8 result in two forms of Batten disease with remarkably similar clinical features. It turns out, as recently shown
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The single cell and the cluster, what makes one better than the other at cancer metastasis?
Cancer metastasis is all about rogue cancer cells abandoning the original tumor and venturing through the blood in search for new breeding grounds. Sometimes, single
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