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From The Labs

Study reveals heterogeneity of bone metastases across different and same cancer types

June 19, 2025 bone metastasis,  Cancer,  immune cells,  macrophages,  monocytes,  osteoclasts,  regulatory exhausted T cells,  Research,  tumor microenvironment

The results of this study suggest a need to investigate different treatment strategies for different immune ecosystem patterns in bone metastases.

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From The Labs

Researchers identified new indicators for HER2+ breast cancer response to therapy

June 17, 2025 Breast Cancer,  CALGB 40601 clinical trial,  GPRC5A,  HER2,  proteogenomics,  Research,  response to treatment,  TPBG

Being able to predict the response of cancer to treatment by analyzing a tumor sample before therapy is given would significantly affect clinical outcomes

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From The Labs

A new treatment can potentially change the outlook for patients with Alagille syndrome

June 12, 2025 Alagille syndrome,  gene therapy,  liver transplant,  Research,  Sox4

Currently, the condition has no definitive treatments other than liver transplant, but the team shows that in mouse models the new therapy can significantly improve liver health and bile duct development – even after liver damage has already begun.

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Two sample tubes.
Momentum

Invisible to the naked eye: Space omics and the need for sample collection guidelines

June 10, 2025 Genetics,  Genome Sequencing,  GENSTAR,  Research,  space travel,  TRISH

The GENESTAR manual establishes guidelines for collecting omics data in a spaceflight context, outlining TRISH’s Space Omics program.

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From The Labs

A novel source of genetic variation influencing childhood brain tumors

June 5, 2025 Cancer,  childhood brain tumor,  DNA methylation,  epigenetics,  germline structural variation,  Research

The researchers hope their findings will lead to improved tools for identifying children at risk or tailoring therapies to individual genetic profiles.

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From The Labs

Alzheimer’s disease affects an organism as a whole

June 3, 2025 Alzheimer's Disease,  Aβ42,  cell atlas,  fruit fly,  Research,  tau,  whole body effect

The Alzheimer’s Disease Fly Cell Atlas may lead to a better understanding of the condition and improved treatments.

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From The Labs

Cell Painting identifies flavonoids that are toxic to bladder cancer cells

May 29, 2025 bladder cancer,  cancer therapies,  flavonoids,  lipid,  Research

With Cell Painting we can now rapidly probe flavonoid libraries and potentially uncover their potential therapeutic value.

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nasa-earth-space-image
From The Labs

Ready for space travel? GENESTAR can track how space affects your health

May 27, 2025 Genestar,  genetics research,  Genome Sequencing,  Healthcare,  omics technologies,  Research,  space travel

GENESTAR is a comprehensive biospecimen collection plan that uses cutting-edge technologies to study genes, proteins and other molecules in the body.

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Diagram showing the process for examining wastewater. Toilet to wastewater treatment plant to sample collection to analysis to community health report.
From The Labs

Measles virus detected in Houston wastewater before cases were reported

May 22, 2025 early detection,  measles,  outbreak,  Research,  virus epidemiology,  wastewater

The findings are relevant and timely as measles cases are increasing in Texas and the rest of the country and the study offers a promising strategy to get ahead of potential outbreaks.

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From The Labs

Let-7 is key to keep pulmonary fibrosis in check

May 20, 2025 AT1 cells,  AT2 cells,  fibrosis,  let-7,  lung disease,  pulmonary fibrosis,  Research,  respiratory failure

The findings can provide opportunities for new drugs and interventions to prevent or slow the progression of this devastating disease.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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