Nuclear, not cytoplasmic CELF1, has a stronger role in muscle wasting
This work is the first to show that the response of muscle to CELF1 overexpression depends on the cellular localization of the protein.
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alternative splicing
AKAP8 and the delicate balance between normal and metastatic states
A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors. “Our laboratory investigates cellular
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Image of the Month: Human breast epithelial cells
Epithelial cells line the lobules (small lobes) and terminal ducts of the breast and carry out the important function of making milk. Cancer scientists, such
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CD44 variants prompt different cancer cell behaviors
Imagine fighting enemies that differ in their susceptibility to the weapon you are using against them. Some will perish, but others will survive the attack
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Alternative splicing is crucial to muscle mass maintenance
Despite the importance that changes in muscle mass have in aging, overall body metabolism and in chronic disease, we still don’t fully understand the mechanisms
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There is more going on in DM1 than just alternative splicing
Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy that affects multiple organ systems. People with this condition develop progressive muscle wasting
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G-quadruplex helps breast cancer survive
For breast cancer, expressing the protein CD44s, instead of CD44v, has a survival advantage. And one of the goals of Dr. Chonghui Cheng lab is to
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Muscle’s path to maturity follows the alternative splicing way
Compare the skeletal muscles of a newborn with those of an adult. While the former can barely move the body, adult muscles can perform record
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Image of the Month: What causes myotonic dystrophy, type1
Myotonic dystrophy, type 1 (DM1) is the second most common cause of muscular dystrophy and numerous other muscle disorders that affect tens of thousands of
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Image of the Month: Mechanisms of cancer survival
Among other studies, the lab of Dr. Chonghiu Cheng is pioneering research projects to better undertsand the role alternative splicing plays in cancer. “We have been
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