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  • Is there hidden meaning in “madness”?
  • Changes in gene p16 create a permissive microenvironment for colon cancer growth
  • A new education and health sciences building, a new era for Baylor and the TMC
  • The link between cancer, obesity and metabolic health
  • Breast cancer tumors remotely disrupt immune response that could stop their own growth

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From The Labs

From The Labs 

Changes in gene p16 create a permissive microenvironment for colon cancer growth

May 25, 2023May 26, 2023APC gene, Colorectal Cancer, DNA methylation, epimutation, p16, polyps, Research, tumor microenvironment

The researchers also developed a strategy that reduced tumor growth and improved survival in tumor-bearing mice.

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From The Labs 

Breast cancer tumors remotely disrupt immune response that could stop their own growth

May 23, 2023May 23, 2023anti-tumor response, bone marrow microenvironment, Breast Cancer, MMP-13, remote immunosuppression, Research

The researchers identified ways to accelerate the restoration of the normal immune response and the efficacy of immunotherapies in animal models.

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From The Labs 

19th Annual Texas Children’s Cancer and Hematology Center Research Symposium

May 18, 2023May 18, 2023Cancer and hematology research symposium, medulloblastoma, Research, sickle cell anemia

Researchers discussed the latest cutting-edge, translational and clinical research focusing on pediatric hematology and oncology.

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From The Labs 

Discovering targetable vulnerabilities in endocrine therapy-resistant breast cancer

May 16, 2023May 16, 2023endocrine therapy-resistant breast cancer, ER+ breast cancer, estrogen receptor 1, fusion genes, pralsetinib, Research, RET kinase

The findings support evaluating targeting kinase enzymes in a clinical trial to treat this type of breast cancer.

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From The Labs 

GlyNAC supplementation improves cognitive decline and brain health in aging

May 11, 2023May 11, 2023Aging, brain health, cognitive decline, glutathione deficiency, GlyNAC, Research

GlyNAC – a combination of precursors of the natural antioxidant glutathione – improved or reversed age-associated cognitive decline in old mice and improved multiple associated defects in the aging brain.

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From The Labs 

Variants of MRTFB gene linked to novel neurodevelopmental disorder

May 9, 2023May 9, 2023actin-binding protein, fruit fly, MRTFB gene, neurodevelopmental disorder, Research, undiagnosed disease

The findings open new avenues to investigate mechanisms that lead to this disorder, offering ideas toward a future treatment for the disease.

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From The Labs 

Neurons lead the way in the development of astrocytes

May 4, 2023May 4, 2023astrocyte development, GABA B receptor, neurons, Research

Neurons trigger a complex pattern of events, some of them unexpected, that direct astrocyte development in a region-specific manner.

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From The Labs 

Image of the Month: The Liver’s biliary tree

May 2, 2023May 2, 2023Alagille syndrome, bile, biliary tree, Image of the month, Research

A healthy mouse liver typically shows a well-developed biliary tree through which bile flows into the intestine to help absorb fats and eliminate toxins.

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From The Labs 

Understanding path to multiple sclerosis leads to a potentially improved therapy

April 27, 2023April 27, 2023autoimmune response, bezafibrate, fingolimod, inflammation, Multiple Sclerosis, myelin degradation, Research, S1P, VLCFA

The findings have clinical implications not just in the treatment of MS but also for other neurodegenerative conditions.

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From The Labs 

A map to study exRNA, a novel form of cell-to-cell communication

April 25, 2023April 25, 2023exRNA, exRNA-eCLIP intersection analysis, liquid biopsy, Research, RNA binding proteins

The exRNA map is a valuable resource to accurately implement early detection and monitor disease processes.

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From the Labs Image of the Month

From The Labs Image of the Month From the Labs: The Liver’s biliary tree

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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