Waking up sleeping beauty – persistent IFN-gamma awakens and activates stem cells via BST2
The researchers show that persistent IFNγ mediates the exhaustion of blood stem cells via BST2 expression.
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From The Labs
Study of spliceosome-targeting cancer therapies reveals an overlooked role of mis-spliced RNAs themselves
Endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection.
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BICRA gene variants linked to a neurodevelopmental disorder
Genetic testing of an undiagnosed condition triggered a study that linked the BICRA to a neurodevelopmental disorder.
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‘Rule-breakers’ help identify novel gene variants that modify risk of late-onset Alzheimer’s disease
Using novel methodologies, researchers identified 216 new gene variants, many previously not suspected to play a role in Alzheimer’s disease.
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Rhesus macaque genome study enhances our understanding of human genetic variation
Substantially improved rhesus macaque genome reference assembly helps answer fundamental questions in genetics, cell biology and physiology.
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The Most Viewed Image of the Month in 2020
‘Transverse view of the sciatic nerve’ placed on top as the most viewed Image of the Month in 2020.
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Making strides in tackling osteoarthritis
This study assesses clinically relevant formulations of platelet-rich plasma that can delay osteoarthritis progression and improve pain.
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From the Labs top five most viewed posts of 2020
During 2020, research news on COVID-19 led the headlines, but significant contributions emerged in other fields as well.
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Nuclear, not cytoplasmic CELF1, has a stronger role in muscle wasting
This work is the first to show that the response of muscle to CELF1 overexpression depends on the cellular localization of the protein.
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Changing the perspective on the ‘Cinderella of the cytoskeleton’
Actin modifications, such as those described here, are increasingly being recognized as key regulators of cytoskeleton dynamics.
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