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From The Labs

Image of the Month: A closer look at metastatic medulloblastoma

May 6, 2025 blood vessels,  brain cancer,  fibroblasts,  medulloblastoma,  meninges,  Metastasis,  Research,  tumor microenvironment

The image captures metastatic medulloblastoma tumor cells (green) intertwined with blood vessels (magenta) in the leptomeninges of a mouse model of the human condition.

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From The Labs

Partners in crime: Metastatic medulloblastoma recruits local fibroblasts to support its spread and growth

May 1, 2025 BMP,  brain cancer,  fibroblast,  leptomeninges,  medulloblastoma,  Metastasis,  PDGF,  Research,  tumor microenvironment

This novel discovery shows how tumor and non-tumor cells work together to create an environment that backs up cancer growth.

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From The Labs

Uncovering drivers of glioma-related epilepsy

March 28, 2023 astrocytes,  brain cancer,  epilepsy,  Glioma,  potassium,  Research,  seizures

A combination of animal model and patient studies reveals new possibilities to control glioma-related seizures and tumor growth.

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From The Labs

Turning the molecular clock back on halts neuroblastoma tumor growth

July 27, 2021 BMAL1,  brain cancer,  molecular clock,  MYCN,  neuroblastoma,  Research,  RORa

Restoring function of the molecular clock blocks tumor growth in advanced neuroblastoma and can make tumors more sensitive to conventional chemotherapy.

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child-creativity-education-97064
Momentum

New therapy for pediatric brain tumors could reduce long-term cognitive issues

May 21, 2018 brain cancer,  Cancer,  Clinical research,  Healthcare,  Julia Bernstein,  pediatrics

When a child is diagnosed with a brain tumor, the first actions usually revolve around ensuring his or her survival. However, brain tumor treatment can

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From The Labs

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

December 12, 2017 Atoh1,  brain cancer,  brain tumor in children,  Cerebellum,  Jak2,  medulloblastoma,  Sonic Hedgehog,  Tyrosine 78

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side

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From The Labs

DNA loops matter for NFIA gene expression in brain tumors

December 7, 2017 3-D DNA loops,  brain cancer,  DNA architecture,  DNA loops,  enhancers,  gene regulation,  Glioma,  NFIA,  transcription factors

The nuclear factor I-A (NFIA) gene is important for both normal brain development and brain tumor growth. One way to discover paths that can lead

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From The Labs

Image of the Month: The underappreciated astrocyte

November 8, 2017 astrocyte,  brain cancer,  glial cells,  Neurological disorders

The brain has billions of cells of which only 30 percent are neurons. Astrocytes are the predominant cell type of the remaining 70 percent. Surprisingly,

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Rierson-photo
Momentum

In the genes: Family quests for glioblastoma answers

December 8, 2014 brain cancer,  brain tumors,  Cancer,  Dr. Melissa Bondy,  Genetics,  glioblastoma multiforme

When glioblastoma hit their family for a second time, sisters Hadley Rierson and Carrie Lebovich teamed up with Baylor College of Medicine’s Dr. Melissa Bondy.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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