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From The Labs

Sprinter and marathoner CAR T cells reveal their distinct cancer-killing behavior

February 4, 2025 cancer treatment,  CAR T cell,  Research,  solid tumors

The study lays a foundation for designing CAR molecules that maximize antitumor activity beyond B cell malignancies.

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Pre- and post-infusion three-dimensional imaging shows that infused GPC3 CAR T cells induce significant antitumor responses in patients.
From The Labs

From bench to bedside and back: CAR T cells armed with IL-15 show promise in treating solid cancers

January 28, 2025 cancer treatment,  CAR T cells,  Clinical Trials,  IL-15,  Research,  solid tumors

Researchers relate their journey to finding a promising method to address CAR T cell challenges in treating solid tumors.

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From The Labs

Study opens new opportunities to develop cancer treatments

June 25, 2024 cancer datasets,  cancer treatment,  drug repurposing,  integrated computational analysis,  Research

The team integrated proteogenomic datasets of more than 1,000 tissue samples spanning 10 cancer types to illuminate protein targets for cancer therapy.

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From The Labs

Path-breaking research reveals new possibilities to improve treatment of endometrial carcinoma

October 12, 2023 cancer treatment,  endometrial cancer,  gynecologic cancers,  PIK3R1-AKT pathway,  proteogenomic characterization,  Research

Detailed molecular characterization of endometrial carcinomas identifies potential markers for guiding more precise treatment.

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From The Labs

Eliminating gene SRC-3 in immune cells triggers effective long-lasting anti-cancer response

June 8, 2023 Breast Cancer,  cancer treatment,  Prostate Cancer,  Research,  SRC-3,  Tregs,  tumor microenvironment

The findings in animal models warrant continuing investigations to develop a novel, more effective and longer-lasting cancer therapy.

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From The Labs

‘Drug factory’ implants eliminate mesothelioma tumors in mice

August 25, 2022 cancer treatment,  checkpoint inhibitors,  IL-2-producing beads,  Mesothelioma,  Research

A Baylor College of Medicine-Rice University collaboration is making strides in the treatment of mesothelioma and other cancers.

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From The Labs

Researchers identify an Achilles’ heel in neuroblastoma

August 16, 2022 cancer treatment,  FATP2,  fatty acid metabolism,  metabolimics,  MYCN,  neuroblastoma,  Research

A metabolic vulnerability in neuroblastoma could be exploited to overturn these tumors’ resistance to therapy.

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From The Labs

A potentially more effective treatment for HER2 mutant metastatic breast cancer

June 23, 2022 Breast Cancer,  cancer treatment,  HER2 mutations,  lobular breast cancer,  Metastasis,  neratinib,  poziotinib,  Research

A phase II clinical trial is on its way to assess the value of poziotinib in the treatment of this devastating condition.

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From The Labs

Molecular profiling identifies new high-risk subtype of pediatric liver cancer

May 24, 2022 cancer treatment,  diagnostic algorithm for cancer,  hepatoblastoma,  hepatocellular carcinoma,  molecular profiling,  pediatric liver cancer,  Research

The findings support a diagnostic algorithm to identify the cancer subtype and guide specialized treatment.

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From The Labs

Study seeks to identify biological markers that predict mesothelioma response to treatment

February 16, 2021 cancer treatment,  grant,  immune checkpoint,  Mesothelioma,  neoantigens,  Research

By taking a close look inside mesothelioma, Dr. B. Burt searches for clues to predict patient’s response to immunotherapy.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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