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From The Labs

Largest study of malignant brain tumors finds new genetic markers for two distinct glioma subtypes

May 5, 2017 brain tumor,  genetic markers,  Genetics,  glioblastoma,  Glioma

In 2017, approximately 24,000 people will be diagnosed with malignant brain tumors and 17,000 will die from the disease in the United States. The most

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From The Labs

ABL1 gene plays a role in cancer and in a developmental disorder

April 18, 2017 ABL1 gene,  Cancer,  Cardiovascular Disease,  Genetics,  genomic data,  Human genetics,  Marfan syndrome,  Philadelphia chromosome

The human gene ABL1 is well-known for its association with cancer. In this case, a piece of chromosome 9 containing the ABL1 gene and a

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From The Labs

Mutations in CWC27 result in spectrum of conditions

April 13, 2017 blindness,  craniofacial and skeletal problems,  CWC27,  Genetics,  Retinitis pigmentosa,  spliceosome,  whole exome sequencing

Mingchu Xu searches for genes linked to retinitis pigmentosa, a condition of the retina characterized by progressive development of night blindness and tunnel vision, sometimes from

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From The Labs

No SOX9, no cartilage; and how DDRGK1 causes a rare human skeletal dysplasia

April 11, 2017 cartilage,  DDRGK1,  dwarfism,  Genetics,  SEMD,  Skeletal dysplasia,  SOX9

SEMD, Shohat-type spondyloepimetaphyseal dysplasia, is a rare type of skeletal dysplasia that affects the development of cartilage and results in a form of dwarfism with a

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From The Labs

How do muscles grow up? Check alternative splicing

January 30, 2017 alternative splicing,  Genetics,  heart muscle,  muscular disorders,  muscular dystrophy,  myotonic dystrophy,  skeletal muscle

Growing up is a complex affair, even for muscles. In the mouse, for instance, newborn muscles grow into adult muscles within the first three weeks

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From The Labs

A pill to prevent Alzheimer’s disease might someday be a reality

January 18, 2017 Alzheimer's Disease,  fruit fly model,  Genetics,  mouse model,  Nuak1,  Parkinson's Disease,  tau

Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer’s disease, according to scientists at

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From The Labs

Improving the view on the genetic causes of retinitis pigmentosa

January 13, 2017 blindness,  CRISPR/Cas9,  Genetics,  REEP6,  Retinitis pigmentosa,  visula impairment

Progressive development of night blindness and tunnel vision, sometimes from the early age of 2, are trademarks of retinitis pigmentosa. Being the most common inherited

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From The Labs

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

January 11, 2017 Cancer,  cancer evolution,  DNA repair,  E. Coli,  Freeze-frames proteins,  Genetics

Cancer scientists have focused on identifying signature genetic changes present in cancerous cells and understanding how these changes lead to cancer. Although this approach has

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From The Labs

Image of the Month: Neuron-muscle synapses in the fruit fly

January 4, 2017 ATAD3A,  Drosophila,  fruit fly,  Genetics,  heart conditions,  low muscular tone,  neurological syndromes,  Neuroscience

Certain human gene variants of ATAD3A can cause rare neurological syndromes characterized by global developmental delay, low muscular tone and visual, neurological and heart problems. The

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From The Labs

Mouse Gata2 gene can affect female fertility and uterine susceptibility to cancer

November 30, 2016 estrogen,  Fertility,  Gata2,  Genetics,  human fertility,  mouse fertility,  progesterone,  uterine cancer

Determining the cause of infertility can be a complex matter. Infertility may be the result of a problem in one or several of the multiple

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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