The researchers show in an animal model that it is possible to change the course of the disease by reprogramming the recycling and waste-disposal system of neurons.
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The findings suggest that modulating the tubulin pool could offer a selective therapeutic strategy.
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This promising line of research may lead to the identification of early diagnosis markers that could be detected in a blood test.
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The findings reveal promising biological pathways that could be explored in future therapies.
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The findings offer new possibilities to restore in people disruptions in dopamine that have been associated with disorders such as addiction, depression, sleep disorders and schizophrenia.
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The Causal Pivot accounts for genetic diversity within a disease and can be adapted to the clinic of tomorrow.
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This model can help identify new disease biomarkers and test therapies that could alter its progression, maybe even prevent the condition.
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Allison Toepperwein and her husband Steven share their experience with deep brain stimulation for the treatment of movement disorders.
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This work potentially contributes an important new piece of the puzzle regarding the development of Alzheimer’s disease.
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Disruption of sphingolipid metabolism led to neurodegeneration in animal models, revealing a new molecular path to Gaucher’s disease.
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