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From The Labs

TULIPs in brain tumors could be exploited therapeutically

August 15, 2024 brain tumor,  ependymoma,  histone methylation,  PFA,  Research,  TULIP,  tumor genome

TULIPs are 3D genome features in PFA ependymoma that are not present in other types of pediatric brain cancer.

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From The Labs

Neuron-glioblastoma conversations across the brain spark tumor invasion

August 10, 2023 brain tumor,  glioblastoma,  neuron,  Research,  SEMA4F,  tumor infiltration

The findings suggest SEMA4F is an essential factor for glioma progression and neuronal activity-dependent infiltration.

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From The Labs

Unanticipated findings cast new light on the genetic regulation of different brain tumors

July 21, 2022 brain tumor,  ependymoma,  epigenetics,  EPN,  gene regulation,  HGG,  high-grade glioma,  Research,  SOX9,  tumor behavior

The findings highlight the importance of considering the mechanisms of gene regulation involved in different tumors when planning therapies.

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A doctor looking at brain scans from a patient, who is in an MRI machine
Momentum

What you need to know about glioblastoma

July 20, 2022 brain tumor,  Dan L Duncan Comprehensive Cancer Center,  glioblastoma

Dr. Jacob Mandel discusses what glioblastoma is and how it can be treated.

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From The Labs

Like a mastermind of its own destiny, glioma sets a stage that favors its own growth

March 10, 2020 brain tumor,  Glioma,  glypican,  PIK3CA,  Research,  synaptic remodeling

“In some regards, glioma brain tumors exhibit Machiavellian behavior,” said Dr. Benjamin Deneen. Machiavellian, as in scheming and cunning, comes from the Italian philosopher Niccolò

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From The Labs

Special delivery of IL-7 signaling makes all the difference for CAR T cells fighting solid tumors

May 15, 2018 brain tumor,  CAR T cells,  IL7,  Immunotherapy,  Research,  solid tumors

Since he was in college, Thomas Shum wanted to pursue a career in cancer research. As he advanced in his studies, he was able to

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From The Labs

Largest study of malignant brain tumors finds new genetic markers for two distinct glioma subtypes

May 5, 2017 brain tumor,  genetic markers,  Genetics,  glioblastoma,  Glioma

In 2017, approximately 24,000 people will be diagnosed with malignant brain tumors and 17,000 will die from the disease in the United States. The most

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From The Labs

The underappreciated astrocyte; a vital link between brain tumors and epileptic seizures

March 30, 2017 astrocyte,  brain tumor,  epilepsy,  glioblastoma,  neurons,  seizures

The brain has billions of cells of which only 30 percent are neurons. Astrocytes are the predominant cell type of the remaining 70 percent. Surprisingly,

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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