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From The Labs

Sorting out cell type-specific molecular barcodes

July 14, 2020 CluBCpG,  DNA methylation,  epigenetics,  PReLIM,  Research,  WGBS

Researchers at Baylor College of Medicine developed novel software that can distinguish methylation patterns within bulk WGBS data.

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From The Labs

No NELL2, no sperm motility. Novel protein is essential for male fertility

July 9, 2020 lumicrine signaling,  male fertility,  NELL2,  Research,  Ros1,  sperm motility

An international team of researchers has identified a chain of events that matures the sperm and triggers their motility.

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From The Labs

Metabolomics meets genomics to improve patient diagnosis

July 7, 2020 genetic diagnosis,  Genomics,  metabolomics,  Research,  undiagnosed disease

Researchers at Baylor College of Medicine have improved their ability to identify the genetic cause of undiagnosed conditions.

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From The Labs

Image of the Month: Locating molecular players in Batten disease

July 2, 2020 Batten disease,  childhood disease,  CLN6,  CLN8,  Lysosomal storage disorder,  neurodevelopmental disorder,  Research

Researchers at Baylor College of Medicine discovered how defective protein CLN6 can result in Batten disease.

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From The Labs

The single cell and the cluster, what makes one better than the other at cancer metastasis?

June 30, 2020 Breast Cancer,  cluster cancer cells,  Metastasis,  NK cells,  Research

Cancer metastasis is all about rogue cancer cells abandoning the original tumor and venturing through the blood in search for new breeding grounds. Sometimes, single

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From The Labs

Understanding the cancer risk in children with birth defects

June 25, 2020 ALL,  Birth defects,  cancer risk,  hepatoblastoma,  neuroblastoma,  pediatric oncology,  Research

Understanding the cancer risk in children with birth defects has been a challenge. Although scientific studies suggest that birth defects increase the risk of cancer,

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From The Labs

Slow-growing rotavirus mutant reveals early steps of viral assembly

June 23, 2020 lipid droplets,  NSP2,  phosphomimetics,  Research,  rotavirus,  viroplasm

Rotavirus is responsible for more than 130,000 deaths annually in infants and children younger than five years. The virus causes severe, dehydrating diarrhea as it

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From The Labs

Unique sugar-sensing neurons work together to prevent severe hypoglycemia in mice.

June 18, 2020 Diabetes,  estrogen receptor,  hypoglycemia,  low blood sugar,  Research,  sugar-sensing neurons

Keeping blood sugar in balance can be a challenge, especially for people with type 1 diabetes who rely on intensive insulin therapy to prevent blood

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From The Labs

Premature epigenomic aging acts like a ‘sleeper cell’ that is awaken by Western-style diet

June 16, 2020 early aging,  endocrine-disrupting chemicals,  environmental disruption,  epigenome,  liver disease,  metabolic disease,  Research

The epigenome is sometimes referred to as the “software” or “operating system” of the genome. It comprises small chemical modifications to DNA and the proteins

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From The Labs

A novel mechanism that triggers a cellular immune response

June 11, 2020 Cancer,  cell-mediated immune response,  dendritic cells,  MHC Class I,  MHC Class II,  Research,  Vaccines,  viral infection

Viruses and other disease-causing microbes influence the type of immune response their hosts will develop against them. In some cases, the predominant response involves antibodies,

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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