Targeting MAPK4 emerges as a promising therapy for prostate cancer

The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease.

Model of prostate cancer. Courtesy of NCI/NIH

Studying a little-known MAPK enzyme called MAPK4, Dr. Feng Yang and his colleagues at Baylor College of Medicine and other institutions discovered that inhibiting MAPK4 activity in prostate cancer might help fight this disease that is the second leading cause of cancer death in American men.

Dr. Feng Yang

“Scientists already knew that both the androgen receptor (AR) and the AKT cellular pathways can drive prostate cancer,” said Yang, assistant professor of molecular and cellular biology, member of the Dan L Duncan Comprehensive Cancer Center at Baylor and corresponding author of the work. “One complication with targeting AR (for instance, with medical castration therapy, including the most advanced agents such as enzalutamide, apalutamide and abiraterone) or AKT is that there is a reciprocal crosstalk between these pathways. When AR is inhibited, AKT gets activated, and vice-versa, therefore tackling these pathways to control cancer growth is complex.”

In previous work, the Yang lab studied the little-known enzyme MAPK4.

“One interesting aspect of MAPK4 is that it is rather unique because it does not work as conventional MAPK enzymes do,” Yang said.

To our knowledge, we are one of the few groups studying MAPK4 and the first to uncover its critical roles in human cancers.”

In their previous study, Yang and his colleagues discovered that MAPK4 can trigger the AKT pathway, not only in prostate cancer but in other cancers as well, such as lung and colon cancers.

In the current study, the researchers found that MAPK4 also activates the AR signaling pathway by enhancing the production and stabilization of GATA2, a factor that is crucial for the synthesis and activation of AR.

Further experiments showed that MAPK4 triggered the concerted activation of both AR and AKT pathways by independent mechanisms, and this promoted prostate cancer growth and resistance to castration therapy, a standard treatment for advanced/metastatic prostate cancer.

Importantly, genetically knocking down MAPK4 reduced the activation of both AR and AKT pathways and inhibited the growth, including castration-resistant growth, of prostate cancer in animal models.”

The researchers anticipate that knocking down MAPK4 also could reduce the growth of other cancer types in which MAPK4 is involved.

Image courtesy of the Yang lab/Journal of Clinical Investigation, 2021

“Our findings suggest the possibility that regulating MAPK4 activity could result in a novel therapeutic approach for prostate cancer,” Yang said. “We are interested in finding an inhibitor of MAPK4 activity that could help better treat prostate cancer and other cancer types in the future.”

The study appeared in Journal of Clinical Investigation.

Other contributors to this work include Tao Shen, Wei Wang, Wolong Zhou, Ilsa Coleman, Qinbo Cai, Bingning Dong, Michael M. Ittmann, Chad J. Creighton, Yingnan Bian, Yanling Meng, David R. Rowley, Peter S. Nelson and David D. Moore. The authors are affiliated with one or more of the following institutions: Baylor College of Medicine; Fred Hutchinson Cancer Research Center, Seattle; Adrienne Helis Malvin Medical Research Foundation, New Orleans and University of Washington, Seattle.

This research was supported by grants from the Department of Defense Congressionally Directed Medical Research Programs (W81XWH-13-1-0162, W81XWH-13-1-0163, W81XWH-17-1-0043) and the Cancer Prevention Research Institute of Texas (RP130651).

 

By Ana María Rodríguez, Ph.D.

 

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