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From The Labs

Targeting MAPK4 may offer a new therapeutic opportunity for TNBC

January 27, 2022 AKT, cancer therapy, MAPK4, PI3K, PI3K inhibitor, Research, triple-negative breast cancer

MAPK4 seems to be involved in promoting triple-negative breast cancer growth and its resistance to certain therapies.

From The Labs

Expanding the diagnosis for Xia-Gibbs Syndrome

September 7, 2021 diagnosis, missense mutations, rare disease, Research, Xia-Gibbs syndrome

Researchers at Baylor College of Medicine have validated a new type of genetic mutation that causes Xia-Gibbs Syndrome, a rare genetic disorder.

From The Labs

Eating for hunger or pleasure? This is how the brain handles these feeding behaviors

August 26, 2021 brain circuit, GABA A receptor, hunger, ion channel, Research, serotonin, serotonin 1B receptor, serotonin 2C receptor

The researchers found that each type of feeding is wired by its own independent circuit that does not influence the other type.

From The Labs

Targeting MAPK4 emerges as a promising therapy for prostate cancer

February 23, 2021 Akt pathway, androgen receptor, cancer therapy, castration-resistant prostate cancer, MAPK4, Prostate Cancer, Research

Inhibiting MAPK4 simultaneously inactivated both androgen receptor and AKT and stopped cancer growth in animal models.

From The Labs

Novel PROTAC has a two-front improvement

September 3, 2020 BTK, PROTAC, protein degrader, Research, reversible covalent chemical binder

Researchers developed a novel PROTAC with enhanced intracellular accumulation and improved ability to neutralize target proteins inside cells.

From The Labs

CAR T cell therapy makes strides in tackling Hodgkin lymphoma

August 11, 2020 blood cancer, CAR T cell therapy, fludarabine, Hodgkin lymphoma, Research

CAR-T cell therapy has been used to treat Hodgkin lymphoma with remarkable success for the first time in an early phase clinical trial.

From The Labs

Unique sugar-sensing neurons work together to prevent severe hypoglycemia in mice.

June 18, 2020 Diabetes, estrogen receptor, hypoglycemia, low blood sugar, Research, sugar-sensing neurons

Keeping blood sugar in balance can be a challenge, especially for people with type 1 diabetes who rely on intensive insulin therapy to prevent blood

From The Labs

A potential Achilles’ heel of breast cancer bone metastasis

December 6, 2018 Achilles' heel, bone metastasis, bone-in-culture, Breast Cancer, calcium, mTOR, Research

Researchers have found that the bone microenvironment can promote the growth and progression of breast cancer micrometastasis, a small group of cancer cells that separates

From The Labs

Device that induces a mild localized ‘fever’ could treat vascular involvement in cancer

November 2, 2017 CorleyWare device, hyperthermia, Innovation in cancer treatment, innovative technology, Metastasis, pancreatic cancer, positive margin

The prognosis of a cancer patient relies significantly on the ability of the surgeon to remove all the tumor, including a cancer-free boundary, leaving what

From The Labs

Collaboration matters when looking for answers to undiagnosed diseases

February 10, 2017 data sharing, de novo mutation, developmental delay, Human genetics, NACC1, Rare Diseases, undiagnosed diseases, whole exome sequencing

It used to be that identifying genes involved in a particular disease was like finding a needle in a haystack. Nowadays, scientists still have to