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Author: Ana Rodríguez

From The Labs 

A new mechanism of cisplatin resistance in cancer, and how to reverse it

April 22, 2021April 22, 2021 Ana Rodríguez 0 Comments ACTL6A, cancer resistance to therapy, cisplatin, DNA repair, epigenetic chromatin remodeling, panobinostat, Research

ACLT6A overexpression confers cancer cells resistance to cisplatin, and researchers found a way to reverse it.

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From The Labs 

POT1 gene mutation predisposes to glioma and affects survival in a sex-specific manner

April 20, 2021April 20, 2021 Ana Rodríguez 0 Comments Cancer, Glioma, POT1, Research, tumor immune infliltration

Researchers found gender differences in murine glioma lacking the gene Pot1, including survival, immune response, telomere length and DNA markers.

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From The Labs 

Selecting the right deconvolution method just got easier

April 15, 2021April 15, 2021 Ana Rodríguez 0 Comments analysis of complex cell populations, deconvolution methods, Research, RNA-seq

Extensive evaluation of existing deconvolution methods produced guidelines that scientists can use to determine the method that optimally fits their needs.

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From The Labs 

Closer to human – mouse model more accurately reproduces fatty liver disease

April 13, 2021April 13, 2021 Ana Rodríguez 0 Comments chimeric mouse model, fatty liver disease, NAFLD, Research

A mouse model that closely replicates fatty liver disease can be used to better understand the condition and identify effective therapies.

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From The Labs 

Prolonged infection and inflammation drain immune responses as we age

April 8, 2021April 8, 2021 Ana Rodríguez 0 Comments Aging, clonal hematopoiesis, Dnmt3a, hematopoietic stem cells, IFNgamma, inflammation, prolonged infection, Research

Sustained infection and inflammation wear down the immune system as we age reducing its ability to fight disease.

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From The Labs 

Fine-tuning deep brain stimulation plus exercise restore movement in ataxia

April 6, 2021April 6, 2021 Ana Rodríguez 0 Comments ataxia, deep brain stimulation, Purkinje cells, Research

A precise combination of DBS and exercise rescued and maintained limb coordination and stepping in mice without further stimulation.

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From The Labs 

Image of the Month: Training and neuronal activation in Rett mice

April 1, 2021April 1, 2021 Ana Rodríguez 0 Comments mental and motor dissability, neuronal arborization, physical training, Research, Rett Syndrome

Early physical training triggers more dendritic arbors or cellular projections in hippocampal neurons (red), enhancing their functionality.

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From The Labs 

Phages can prevent infection before it happens

March 30, 2021March 30, 2021 Ana Rodríguez 0 Comments Antibiotic-resistant bacteria, epithelial cella, ES17 phage, ExPEC bacteria, heparan sulfate, mucins, phages, Research

Researchers have identified a novel strategy that can eliminate bacteria in a specific location before they cause an infection.

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From The Labs 

Research opens new possibilities to improve the lives of girls with Rett syndrome

March 25, 2021March 25, 2021 Ana Rodríguez 0 Comments neuron arborization, physical training, Research, Rett Syndrome

In a mouse model of Rett syndrome, early intensive training substantially delayed the appearance of symptoms and improved performance.

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From The Labs 

The multitasking nature of SRC-3

March 23, 2021March 23, 2021 Ana Rodríguez 0 Comments Breast Cancer, cancer survival, immune system, Research, SRC-3, steroid hormone, T regulatory cells

SRC-3 not only influences steroid hormone function and gives a heads up for aggressive human breast cancer, it also regulates immune T cells.

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From the Labs Image of the Month

From The Labs Image of the Month From the Labs features an image of early physical training of Rett mice, which results in the development of more dendritic arbors or cellular projections in a task-specific group of neurons in the hippocampus (red). Image credit: N.P. Achilly/Zoghbi lab/Nature, 2021.

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