Currently, the condition has no definitive treatments other than liver transplant, but the team shows that in mouse models the new therapy can significantly improve liver health and bile duct development – even after liver damage has already begun.
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A healthy mouse liver typically shows a well-developed biliary tree through which bile flows into the intestine to help absorb fats and eliminate toxins.
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The findings show that it is possible to promote the formation of a near-normal biliary tree in animals that already have a poorly developed biliary tree.
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From the Labs interviewed Dr. Joshua M. Adams to learn about his experiences during his training in Baylor College of Medicine‘s M.D./Ph.D. program. He has
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Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues. One major characteristic of
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