Alagille syndrome Archives - Baylor College of Medicine Blog Network

A healthy mouse liver typically shows a well-developed biliary tree through which bile flows into the intestine to help absorb fats and eliminate toxins.

From The Labs

Preventing liver damage in animal models of Alagille syndrome

April 11, 2023April 11, 2023Alagille syndrome, antisense oligonucleotide, biliary tree, cholestasis, JAG1, POGLUT1, Research

The findings show that it is possible to promote the formation of a near-normal biliary tree in animals that already have a poorly developed biliary tree.

From The Labs

From my perspective: Dr. Joshua Adams shares his experiences in Baylor College of Medicine’s M.D./Ph.D. program

October 24, 2019October 24, 2019Alagille syndrome, MD/PhD program, Research

From the Labs interviewed Dr. Joshua M. Adams to learn about his experiences during his training in Baylor College of Medicine‘s M.D./Ph.D. program. He has

From The Labs

Sox9 reshapes the biliary tree in Alagille syndrome

October 10, 2019October 10, 2019Alagille syndrome, bile, bile tree, cholestasis, intrahepatic bile ducts, JAG1, liver, Notch signaling, Research, SOX9

Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues. One major characteristic of