Research Archives - Page 35 of 80 - Baylor College of Medicine Blog Network

Fasting lowers blood pressure by reshaping the gut microbiota

April 29, 2021 animal model, bile acids, fasting, gut microbiota, Hypertension, Research

For the first time researchers show that intermittent fasting can reduce hypertension by reshaping the gut microbiota in an animal model.

From The Labs

Focused on the Heart — Novel mouse model of myotonic dystrophy displays reversible cardiac disease features of the condition

April 27, 2021 alternative splicing, arrhythmias, cardiac function, DM1, DMPK gene, mouse model, myotonic dystrophy, Research

This model of DM1 allows researchers to both focus on cardiac mechanisms of the disease and to expand therapeutics to target the heart.

From The Labs

A new mechanism of cisplatin resistance in cancer, and how to reverse it

April 22, 2021 ACTL6A, cancer resistance to therapy, cisplatin, DNA repair, epigenetic chromatin remodeling, panobinostat, Research

ACLT6A overexpression confers cancer cells resistance to cisplatin, and researchers found a way to reverse it.

From The Labs

POT1 gene mutation predisposes to glioma and affects survival in a sex-specific manner

April 20, 2021 Cancer, Glioma, POT1, Research, tumor immune infliltration

Researchers found gender differences in murine glioma lacking the gene Pot1, including survival, immune response, telomere length and DNA markers.

From The Labs

Selecting the right deconvolution method just got easier

April 15, 2021 analysis of complex cell populations, deconvolution methods, Research, RNA-seq

Extensive evaluation of existing deconvolution methods produced guidelines that scientists can use to determine the method that optimally fits their needs.

From The Labs

Closer to human – mouse model more accurately reproduces fatty liver disease

April 13, 2021 chimeric mouse model, fatty liver disease, NAFLD, Research

A mouse model that closely replicates fatty liver disease can be used to better understand the condition and identify effective therapies.

From The Labs

Prolonged infection and inflammation drain immune responses as we age

April 8, 2021 Aging, clonal hematopoiesis, Dnmt3a, hematopoietic stem cells, IFNgamma, inflammation, prolonged infection, Research

Sustained infection and inflammation wear down the immune system as we age reducing its ability to fight disease.

From The Labs

Fine-tuning deep brain stimulation plus exercise restore movement in ataxia

April 6, 2021 ataxia, deep brain stimulation, Purkinje cells, Research

A precise combination of DBS and exercise rescued and maintained limb coordination and stepping in mice without further stimulation.

From The Labs

Image of the Month: Training and neuronal activation in Rett mice

April 1, 2021 mental and motor dissability, neuronal arborization, physical training, Research, Rett Syndrome

Early physical training triggers more dendritic arbors or cellular projections in hippocampal neurons (red), enhancing their functionality.

From The Labs

Phages can prevent infection before it happens

March 30, 2021 Antibiotic-resistant bacteria, epithelial cella, ES17 phage, ExPEC bacteria, heparan sulfate, mucins, phages, Research

Researchers have identified a novel strategy that can eliminate bacteria in a specific location before they cause an infection.