PBRM1’s new function supports a novel cancer-promoting mechanism
New findings suggest that cancer-associated defects in chromatin remodeler genes can drive cancer by disrupting cytoskeletal activities.
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SETD2
Changing the perspective on the ‘Cinderella of the cytoskeleton’
Actin modifications, such as those described here, are increasingly being recognized as key regulators of cytoskeleton dynamics.
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Chromosome remodeler SETD2 also remodels the cytoskeleton in kidney cancer cells
Kidney cancer begins when certain genes mutate and, as a result, alter how key molecules work. One of these key molecules is SETD2, which is
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