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From The Labs

Long-term survival supports the potential benefit of CAR T cell therapy to treat solid tumors

February 27, 2025 CAR T cell therapy,  Clinical Trials,  disease free,  longest survival,  neuroblastoma,  Research,  solid tumors

An 18-year survivor of neuroblastoma is believed to represent the longest reported remission to date in a patient treated with chimeric antigen receptor (CAR) T cell therapy.

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From The Labs

Researchers identify an Achilles’ heel in neuroblastoma

August 16, 2022 cancer treatment,  FATP2,  fatty acid metabolism,  metabolimics,  MYCN,  neuroblastoma,  Research

A metabolic vulnerability in neuroblastoma could be exploited to overturn these tumors’ resistance to therapy.

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From The Labs

Turning the molecular clock back on halts neuroblastoma tumor growth

July 27, 2021 BMAL1,  brain cancer,  molecular clock,  MYCN,  neuroblastoma,  Research,  RORa

Restoring function of the molecular clock blocks tumor growth in advanced neuroblastoma and can make tumors more sensitive to conventional chemotherapy.

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From The Labs

CAR NKT cells, a promising step forward in the treatment of solid tumors

November 10, 2020 CAR NK T cells,  clinical trial,  Immunotherapy,  neuroblastoma,  Research,  solid tumors

An ongoing clinical trial shows that human CAR NKT cells are safe and, in 1 of 3 patients, induced regression of metastatic lesions.

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From The Labs

Understanding the cancer risk in children with birth defects

June 25, 2020 ALL,  Birth defects,  cancer risk,  hepatoblastoma,  neuroblastoma,  pediatric oncology,  Research

Understanding the cancer risk in children with birth defects has been a challenge. Although scientific studies suggest that birth defects increase the risk of cancer,

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From The Labs

From the labs to bedside: First-in-human trial shows promise in treating neuroblastoma

May 28, 2019 chimeric antigen,  Clinical Trials,  GD2,  GD2-CAR,  Immunotherapy,  neuroblastoma,  Research

Neuroblastoma is the most common extracranial solid cancer in children, and patients with high-risk disease are challenging to treat. In April, during the annual meeting of

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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