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From The Labs

Image of the Month: A closer look at metastatic medulloblastoma

May 6, 2025 blood vessels,  brain cancer,  fibroblasts,  medulloblastoma,  meninges,  Metastasis,  Research,  tumor microenvironment

The image captures metastatic medulloblastoma tumor cells (green) intertwined with blood vessels (magenta) in the leptomeninges of a mouse model of the human condition.

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From The Labs

Partners in crime: Metastatic medulloblastoma recruits local fibroblasts to support its spread and growth

May 1, 2025 BMP,  brain cancer,  fibroblast,  leptomeninges,  medulloblastoma,  Metastasis,  PDGF,  Research,  tumor microenvironment

This novel discovery shows how tumor and non-tumor cells work together to create an environment that backs up cancer growth.

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From The Labs

Fatty acids promote immune suppression and therapy resistance in triple negative breast cancer

April 22, 2025 immune suppression,  lipids,  neutrophils,  Omega-6 fatty acids,  Research,  triple-negative breast cancer,  tumor microenvironment

The researchers show that disrupting lipid formulation reverses treatment resistance and the immunosuppressive microenvironment.

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From The Labs

Eliminating gene SRC-3 in immune cells triggers effective long-lasting anti-cancer response

June 8, 2023 Breast Cancer,  cancer treatment,  Prostate Cancer,  Research,  SRC-3,  Tregs,  tumor microenvironment

The findings in animal models warrant continuing investigations to develop a novel, more effective and longer-lasting cancer therapy.

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From The Labs

Changes in gene p16 create a permissive microenvironment for colon cancer growth

May 25, 2023 APC gene,  Colorectal Cancer,  DNA methylation,  epimutation,  p16,  polyps,  Research,  tumor microenvironment

The researchers also developed a strategy that reduced tumor growth and improved survival in tumor-bearing mice.

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From The Labs

Taking a closer look into the tumor microenvironment with nano-radiomics

July 28, 2020 cancer treatment,  nano-radiomics,  research; immunotherapy,  tumor microenvironment

Nano-radiomics analysis of imaging data assesses changes in the tumor microenvironment that cannot be detected with conventional imaging methods.

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From The Labs

What extensive protein analysis revealed about cancer

January 21, 2020 Cancer,  cancer proteome analysis,  cancer subtypes,  Research,  tumor microenvironment

Cancer is currently understood not as a single disease, but as a collection of diseases that can develop through alterations in different molecular pathways. This

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From The Labs

What to expect within the tumor microenvironment

September 17, 2019 Breast Cancer,  breast cancer diversity,  immune cells in tumor,  macrophages,  neutrophils,  Research,  tumor microenvironment

Breast cancer is very heterogeneous. For many years researchers have recognized different subtypes of breast cancer, for instance, estrogen receptor positive (ER+), ER- and triple

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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