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From The Labs

Image of the Month: A closer look at metastatic medulloblastoma

May 6, 2025 blood vessels,  brain cancer,  fibroblasts,  medulloblastoma,  meninges,  Metastasis,  Research,  tumor microenvironment

The image captures metastatic medulloblastoma tumor cells (green) intertwined with blood vessels (magenta) in the leptomeninges of a mouse model of the human condition.

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From The Labs

Partners in crime: Metastatic medulloblastoma recruits local fibroblasts to support its spread and growth

May 1, 2025 BMP,  brain cancer,  fibroblast,  leptomeninges,  medulloblastoma,  Metastasis,  PDGF,  Research,  tumor microenvironment

This novel discovery shows how tumor and non-tumor cells work together to create an environment that backs up cancer growth.

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From The Labs

Gene splicing gone wrong leads to aggressive medulloblastoma

August 27, 2024 alternative splicing,  medulloblastoma,  OTX2,  pediatric brain cancer,  PPHLN1,  Research

Disturbing OTX2’s gene-splicing ability reduced tumor growth, opening possibilities for improved treatments.

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From The Labs

19th Annual Texas Children’s Cancer and Hematology Center Research Symposium

May 18, 2023 Cancer and hematology research symposium,  medulloblastoma,  Research,  sickle cell anemia

Researchers discussed the latest cutting-edge, translational and clinical research focusing on pediatric hematology and oncology.

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From The Labs

Atoh1, a potential Achilles’ heel of Sonic Hedgehog MB

December 12, 2017 Atoh1,  brain cancer,  brain tumor in children,  Cerebellum,  Jak2,  medulloblastoma,  Sonic Hedgehog,  Tyrosine 78

Medulloblastoma is the most common type of solid brain tumor in children. Current treatments offer limited success and may leave patients with severe neurological side

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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