Rearranging genomic structure rewires gene control in cancer
Widespread DNA damage is common in the cancer genome. Understanding the mechanisms that lead to it is of great interest to cancer physicians and scientists
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Getting to know TP53 better
TP53 is well known for its role as a tumor suppressor. It senses cellular stress or damage and in response stops cell division or initiates
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What altered gene regulatory regions can do for cancer
The genome includes genes – sequences of DNA that encode the proteins that keep our body working – and regulatory regions adjacent to genes, which
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The Cancer Genome Atlas ten-year study produces game changers for translational research
Historically, cancer patients have been classified according to the organs where primary tumors present at diagnosis, and clinical trials commonly test drugs that are designed
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Common altered pathways provide new cancer perspective
Studying cancer at the molecular level has revealed that there is not a single pathway or process that drives all the different types of cancer.
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Opening a window into the world of tumors
A tumor behaves like a community in which cancerous and normal cells interact with each other. In some cases, these interactions result in tumor growth,
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How understanding tumor diversity can potentially improve the outcomes of patients with lung cancer
[See video below] “People may think of lung cancer as one disease, but lung cancer is a collection of diverse subtypes of cells and each
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