Ana Rodríguez, Author at Baylor College of Medicine Blog Network

Researchers discover novel regulators of myelin repair and regeneration

September 15, 2020 Daam2, glial cells, myelin repair, Nedd4, oligodendrocytes, Research

This work offers new possibilities to potentially repair and regenerate damaged myelin after an injury or in myelin-associated neurological disorders.

From The Labs

Novel PROTAC has a two-front improvement

September 3, 2020 BTK, PROTAC, protein degrader, Research, reversible covalent chemical binder

Researchers developed a novel PROTAC with enhanced intracellular accumulation and improved ability to neutralize target proteins inside cells.

From The Labs

Image of the Month: E. coli bacteria growing on mini-guts

September 1, 2020 Antibiotic-resistant bacteria, antimicrobials, bacterial infections, Image of the month, infectious disease, phages, Research

Infectious microorganisms, including disease-causing E. coli bacteria (pink) shown in the image, cause a third of all deaths world-wide.

From The Labs

Regulating gene regulatory regions offers a novel mechanism to control ATXN1 levels

August 27, 2020 ataxia, ATXN1, balance problems, gene regulation, microRNA, movement problems, Research, SCA1

Researchers identified a novel mechanism that regulates ATXN1 levels and reduces SCA1 symptoms in animal model.

From The Labs

To be or not to be in the ER, that is the question

August 25, 2020 BMP4, endoplasmic reticulum, ERAD, misfolded proteins, NGLY1, proteasomal degradation, Research

Researchers discovered a new way cells can dispose of misfolded proteins that may help better understand human NGLY1 deficiency.

From The Labs

Fighting cancer with rejection-resistant, ‘off-the-shelf’ therapeutic T cells

August 20, 2020 alloimmune defense receptor, cancer therapy, CAR T cells, Off-the-shelf therapeutic T cells, Research

Baylor College of Medicine researchers extend the life and effectiveness of off-the-shelf, cancer-fighting immune T cells.

From The Labs

The first protease-focused, DNA-encoded chemical library for drug discovery

August 18, 2020 DNA-encoded chemical library, drug discovery, Research

Scientists at Baylor College of Medicine have devised a chemical approach for discovering compounds that could be developed into new drugs.

From The Labs

Novel mechanism connects SPEG, RyR2 and atrial fibrillation

August 13, 2020 atrial fibrillation, heart disease, Research, RyR2, SPEG

Reduced levels of protein kinase SPEG lead to hyperactive calcium channel RyR2 and an increased risk of atrial fibrillation.

From The Labs

CAR T cell therapy makes strides in tackling Hodgkin lymphoma

August 11, 2020 blood cancer, CAR T cell therapy, fludarabine, Hodgkin lymphoma, Research

CAR-T cell therapy has been used to treat Hodgkin lymphoma with remarkable success for the first time in an early phase clinical trial.

From The Labs

Tackling the root cause of treatment resistance in age-related macular degeneration

August 6, 2020 AIBP, anti-VEGF, blindness, cholesterol, choroidal neovascularization, macrophages, macular degeneration, Research

A novel strategy can potentially address a major challenge to the current treatment for CNV, the leading cause of irreversible blindness in the elderly.