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From The Labs

PBRM1’s new function supports a novel cancer-promoting mechanism

October 14, 2021 Cancer,  chromatin remodeler,  cytoskleleton remodeler,  genomic instability,  kidney cancer,  PBRM1,  Research,  SETD2,  tubulin methylation

New findings suggest that cancer-associated defects in chromatin remodeler genes can drive cancer by disrupting cytoskeletal activities.

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From The Labs

Changing the perspective on the ‘Cinderella of the cytoskeleton’

December 23, 2020 actin,  Cancer,  cytoskeleton,  filaments,  HTT,  methylation,  microtubules,  Research,  SETD2,  WHAMM

Actin modifications, such as those described here, are increasingly being recognized as key regulators of cytoskeleton dynamics.

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From The Labs

Chromosome remodeler SETD2 also remodels the cytoskeleton in kidney cancer cells

August 30, 2016 Cancer,  chromosome remodeler,  cytoskeleton remodeler,  epigenetics,  kidney cancer,  methyl tags,  Research,  SETD2

Kidney cancer begins when certain genes mutate and, as a result, alter how key molecules work. One of these key molecules is SETD2, which is

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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