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DM1

From The Labs 

Nuclear, not cytoplasmic CELF1, has a stronger role in muscle wasting

December 29, 2020December 29, 2020 Ana Rodríguez 0 Comments alternative splicing, CELF1 and MBNL proteins, DM1, DMPK gene, muscle wasting, myotonic dystrophy, Research

This work is the first to show that the response of muscle to CELF1 overexpression depends on the cellular localization of the protein.

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From The Labs 

There is more going on in DM1 than just alternative splicing

June 26, 2018June 26, 2018 Ana Rodríguez 2 Comments alternative splicing, AMPK-alpha, DM1, DMPK gene, myotonic dystrophy, PDGFR-beta, Research

Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy that affects multiple organ systems. People with this condition develop progressive muscle wasting

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From The Labs 

Image of the Month: What causes myotonic dystrophy, type1

September 5, 2017 Ana Rodríguez 0 Comments alternative splicing, CELF1 and MBNL proteins, CTG repeat, CUGexp, DM1, DMPK gene, MEF2 transcription factor, muscular dystrophy, myotonic dystrophy, RNA splicing

Myotonic dystrophy, type 1 (DM1) is the second most common cause of muscular dystrophy and numerous other muscle disorders that affect tens of thousands of

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From the Labs Image of the Month

From The Labs Image of the Month From the Labs kicks off the new year with the most viewed Image of the Month of 2020.

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