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From The Labs

Gene splicing gone wrong leads to aggressive medulloblastoma

August 27, 2024 alternative splicing,  medulloblastoma,  OTX2,  pediatric brain cancer,  PPHLN1,  Research

Disturbing OTX2’s gene-splicing ability reduced tumor growth, opening possibilities for improved treatments.

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From The Labs

Focused on the Heart — Novel mouse model of myotonic dystrophy displays reversible cardiac disease features of the condition

April 27, 2021 alternative splicing,  arrhythmias,  cardiac function,  DM1,  DMPK gene,  mouse model,  myotonic dystrophy,  Research

This model of DM1 allows researchers to both focus on cardiac mechanisms of the disease and to expand therapeutics to target the heart.

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From The Labs

Nuclear, not cytoplasmic CELF1, has a stronger role in muscle wasting

December 29, 2020 alternative splicing,  CELF1 and MBNL proteins,  DM1,  DMPK gene,  muscle wasting,  myotonic dystrophy,  Research

This work is the first to show that the response of muscle to CELF1 overexpression depends on the cellular localization of the protein.

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From The Labs

AKAP8 and the delicate balance between normal and metastatic states

March 12, 2020 AKAP8,  alternative splicing,  Breast Cancer,  CD44,  CLSTN1,  metastatis,  Research

A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors. “Our laboratory investigates cellular

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From The Labs

Image of the Month: Human breast epithelial cells

February 4, 2020 alternative splicing,  Breast Cancer,  Human breast epithelial cells,  Research

Epithelial cells line the lobules (small lobes) and terminal ducts of the breast and carry out the important function of making milk. Cancer scientists, such

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From The Labs

CD44 variants prompt different cancer cell behaviors

February 21, 2019 alternative splicing,  Breast Cancer,  cancer heterogeneity,  cancer plasticity,  CD44,  Metastasis,  Research,  resistance to treatment

Imagine fighting enemies that differ in their susceptibility to the weapon you are using against them. Some will perish, but others will survive the attack

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From The Labs

Alternative splicing is crucial to muscle mass maintenance

July 10, 2018 Aging,  alternative splicing,  chronic disease,  muscle mass maintenance,  Rbfox1,  Rbfox2,  Research

Despite the importance that changes in muscle mass have in aging, overall body metabolism and in chronic disease, we still don’t fully understand the mechanisms

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From The Labs

There is more going on in DM1 than just alternative splicing

June 26, 2018 alternative splicing,  AMPK-alpha,  DM1,  DMPK gene,  myotonic dystrophy,  PDGFR-beta,  Research

Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy that affects multiple organ systems. People with this condition develop progressive muscle wasting

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From The Labs

G-quadruplex helps breast cancer survive

February 15, 2018 alternative splicing,  Breast Cancer,  CD44,  G-quadruplex

For breast cancer, expressing the protein CD44s, instead of CD44v, has a survival advantage. And one of the goals of Dr. Chonghui Cheng lab  is to

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From The Labs

Muscle’s path to maturity follows the alternative splicing way

November 14, 2017 alternative splicing,  calcineurin A,  calcium-handling proteins,  muscle development,  muscular disorders,  muscular dystrophy

Compare the skeletal muscles of a newborn with those of an adult. While the former can barely move the body, adult muscles can perform record

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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