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Doctor examining a child's neck.
From The Labs

New CDKL genes linked to neurodevelopmental disorders

April 3, 2025 CDKL genes,  dominant negative effect,  fruit fly,  Neurological disorders,  Research,  seizures

Working with fruit flies, the team uncovered a mechanism by which the defective variants may cause the neurological symptoms in affected individuals.

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From The Labs

The cerebellum as a source of generalized convulsive seizures

August 17, 2023 Cerebellum,  cerebral cortex,  convulsions,  epilepsy,  Research,  seizures,  ventral posteromedial nucleus

This is the first study to implicate the cerebellum in altering the activity of neurons in the thalamus to cause generalized seizures.

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From The Labs

Uncovering drivers of glioma-related epilepsy

March 28, 2023 astrocytes,  brain cancer,  epilepsy,  Glioma,  potassium,  Research,  seizures

A combination of animal model and patient studies reveals new possibilities to control glioma-related seizures and tumor growth.

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From The Labs

Brain tumors trigger silencing of neuronal activity

April 21, 2020 brain tumors,  epilepsy,  Glioma,  glutamate dysregulation,  inflammation,  Research,  seizures,  slow depolarization

Sudden episodes of confusion and seizures often are the first signs of a malignant brain tumor. At Baylor College of Medicine, Dr. Jeffrey Noebels, director

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From The Labs

Connecting seizures, neurogenesis and cognitive functions in Alzheimer’s disease

July 18, 2019 Alzheimer's Disease,  neurogenesis,  Research,  seizures

Whether the normal adult human brain produces new neurons, much less those with Alzheimer’s disease, is a controversial topic in the field. While some groups

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From The Labs

Absence epilepsy – when the brain is like ‘an orchestra without a conductor’

June 19, 2018 2-photon microscopy,  absence epilepsy,  childhood epilepsy,  Research,  seizures

At first, the teacher described her six-year-old student as absentminded, a daydreamer. The boy was having difficulty paying attention in class. As the teacher watched

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From The Labs

‘Silent seizures’ discovered in patients with Alzheimer’s disease

July 10, 2017 Alzheimer's Disease,  deep brain,  eeg,  epilepsy,  epileptic seizures,  hippocampus,  nonconvulsive seizures,  seizures

Deep in the brains of two patients with Alzheimer’s disease, the main memory structure, the hippocampus, displays episodic seizure-like electrical activity. These nonconvulsive hippocampal seizures

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From The Labs

The underappreciated astrocyte; a vital link between brain tumors and epileptic seizures

March 30, 2017 astrocyte,  brain tumor,  epilepsy,  glioblastoma,  neurons,  seizures

The brain has billions of cells of which only 30 percent are neurons. Astrocytes are the predominant cell type of the remaining 70 percent. Surprisingly,

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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