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From The Labs

Muscle’s path to maturity follows the alternative splicing way

November 14, 2017 alternative splicing,  calcineurin A,  calcium-handling proteins,  muscle development,  muscular disorders,  muscular dystrophy

Compare the skeletal muscles of a newborn with those of an adult. While the former can barely move the body, adult muscles can perform record

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From The Labs

Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation

September 15, 2017 cardiomyocyte,  DAG1,  heart cell proliferation,  heart disease,  Hippo pathway,  muscular dystrophy,  YAP

Although both are known to play a role in cardiac function and previous work had hinted that they might interact with each other, it was

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From The Labs

Image of the Month: What causes myotonic dystrophy, type1

September 5, 2017 alternative splicing,  CELF1 and MBNL proteins,  CTG repeat,  CUGexp,  DM1,  DMPK gene,  MEF2 transcription factor,  muscular dystrophy,  myotonic dystrophy,  RNA splicing

Myotonic dystrophy, type 1 (DM1) is the second most common cause of muscular dystrophy and numerous other muscle disorders that affect tens of thousands of

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From The Labs

How do muscles grow up? Check alternative splicing

January 30, 2017 alternative splicing,  Genetics,  heart muscle,  muscular disorders,  muscular dystrophy,  myotonic dystrophy,  skeletal muscle

Growing up is a complex affair, even for muscles. In the mouse, for instance, newborn muscles grow into adult muscles within the first three weeks

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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