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RNA splicing

From The Labs

Study of spliceosome-targeting cancer therapies reveals an overlooked role of mis-spliced RNAs themselves

January 19, 2021January 19, 2021 Ana Rodríguez 0 Comments apoptosis, cancer treatment, Immunotherapy, Research, RNA splicing, Spliceosome-targeting therapies, triple-negative breast cancer

Endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection.

From The Labs

Image of the Month: What causes myotonic dystrophy, type1

September 5, 2017 Ana Rodríguez 0 Comments alternative splicing, CELF1 and MBNL proteins, CTG repeat, CUGexp, DM1, DMPK gene, MEF2 transcription factor, muscular dystrophy, myotonic dystrophy, RNA splicing

Myotonic dystrophy, type 1 (DM1) is the second most common cause of muscular dystrophy and numerous other muscle disorders that affect tens of thousands of

From the Labs features a visualization of a novel approach to study gene function in the fruit fly. Image courtesy of the study authors/Cell Reports, 2021.