New research moves novel gene therapy for heart failure closer to the clinic
Knocking down the Hippo signaling pathway in pig cardiomyocytes after a heart attack, resulted in heart tissue renewal and improved function.
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Hippo pathway
Image of the Month: cardiac fibroblasts
This Image of the Month features the cardiac fibroblast, a cell that is central to heart failure, the leading cause of mortality in the U.S.
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What the Hippo pathway in cardiac fibroblasts reveals about heart function
Heart failure remains the leading cause of mortality in the U.S. During a heart attack, blood stops flowing into the heart. Without oxygen, part of
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The Hippo pathway: tailor of the developing heart
The Hippo pathway is an inhibitor of adult heart regeneration; if you take the Hippo pathway away, then the heart can regenerate. But, can the
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Tapping on the healing capacity of the heart
If your skin is injured, it can heal itself. If you lose blood, your body makes more. If a lobe is removed from a mouse
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Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation
Although both are known to play a role in cardiac function and previous work had hinted that they might interact with each other, it was
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