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From The Labs

19th Annual Texas Children’s Cancer and Hematology Center Research Symposium

May 18, 2023 Cancer and hematology research symposium,  medulloblastoma,  Research,  sickle cell anemia

Researchers discussed the latest cutting-edge, translational and clinical research focusing on pediatric hematology and oncology.

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From The Labs

Discovering targetable vulnerabilities in endocrine therapy-resistant breast cancer

May 16, 2023 endocrine therapy-resistant breast cancer,  ER+ breast cancer,  estrogen receptor 1,  fusion genes,  pralsetinib,  Research,  RET kinase

The findings support evaluating targeting kinase enzymes in a clinical trial to treat this type of breast cancer.

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From The Labs

GlyNAC supplementation improves cognitive decline and brain health in aging

May 11, 2023 Aging,  brain health,  cognitive decline,  glutathione deficiency,  GlyNAC,  Research

GlyNAC – a combination of precursors of the natural antioxidant glutathione – improved or reversed age-associated cognitive decline in old mice and improved multiple associated defects in the aging brain.

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From The Labs

Variants of MRTFB gene linked to novel neurodevelopmental disorder

May 9, 2023 actin-binding protein,  fruit fly,  MRTFB gene,  neurodevelopmental disorder,  Research,  undiagnosed disease

The findings open new avenues to investigate mechanisms that lead to this disorder, offering ideas toward a future treatment for the disease.

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From The Labs

Neurons lead the way in the development of astrocytes

May 4, 2023 astrocyte development,  GABA B receptor,  neurons,  Research

Neurons trigger a complex pattern of events, some of them unexpected, that direct astrocyte development in a region-specific manner.

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From The Labs

Image of the Month: The Liver’s biliary tree

May 2, 2023 Alagille syndrome,  bile,  biliary tree,  Image of the month,  Research

A healthy mouse liver typically shows a well-developed biliary tree through which bile flows into the intestine to help absorb fats and eliminate toxins.

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From The Labs

Understanding path to multiple sclerosis leads to a potentially improved therapy

April 27, 2023 autoimmune response,  bezafibrate,  fingolimod,  inflammation,  Multiple Sclerosis,  myelin degradation,  Research,  S1P,  VLCFA

The findings have clinical implications not just in the treatment of MS but also for other neurodegenerative conditions.

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From The Labs

A map to study exRNA, a novel form of cell-to-cell communication

April 25, 2023 exRNA,  exRNA-eCLIP intersection analysis,  liquid biopsy,  Research,  RNA binding proteins

The exRNA map is a valuable resource to accurately implement early detection and monitor disease processes.

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From The Labs

How a mutation in the SKD3 enzyme can cause MGCA7 disease

April 20, 2023 crystal structure,  enzyme activity,  MGCA7 disease,  Research,  SKD3

The researchers propose the first mechanism by which non-catalytic domain mutations in SKD3 can lead to MGCA7.

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From The Labs

Protein Beclin-1 is key for uterine remodeling and the establishment of pregnancy

April 18, 2023 apoptosis,  autophagy,  Beclin-1,  Pregnancy,  Research,  stem cells,  uterine development

The findings have encouraged exploring the development of practical applications in the fields of both contraceptives and infertility.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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