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rotavirus

From The Labs 

Artificial intelligence reveals a never-before described 3D structure in rotavirus spike protein

June 9, 2022June 10, 2022ALphaFold2, gastroenteritis, N-acetyllactosamine, Research, rotavirus, spike protein, VP8*, X-Ray crystallography

The findings are an example of how viruses can evolve by incorporating structurally distinct modules with similar functionality.

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From The Labs 

Image (video) of the Month: human intestinal organoid after infection with rotavirus

March 1, 2022March 1, 2022calcium channels, calcium signalling pathways, FASEB BioArt contest, Research, rotavirus, viroporins

This video placed first in the 2021 FASEB BioArt contest: video category. Congratulations, JT Gebert and the Hyser lab!

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From The Labs 

How a few rotavirus can cause severe gastrointestinal disease

December 8, 2020December 8, 2020ADP, calcium waves, diarrhea, Research, rotavirus, serotoning, vomiting

Using intercellular calcium waves, rotavirus amplifies its ability to cause disease beyond the cells it directly infects.

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From The Labs 

Slow-growing rotavirus mutant reveals early steps of viral assembly

June 23, 2020June 23, 2020lipid droplets, NSP2, phosphomimetics, Research, rotavirus, viroplasm

Rotavirus is responsible for more than 130,000 deaths annually in infants and children younger than five years. The virus causes severe, dehydrating diarrhea as it

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VP3-news-20200410-v4 cropped modified 1
From The Labs 

Mystery solved, rotavirus VP3 is a unique capping machine

April 23, 2020April 23, 2020mRNA capping, Research, rotavirus, VP3

After eluding researchers for more than 30 years, the VP3 protein of rotavirus has finally revealed its unique structure and function to a team led

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From The Labs 

‘Give me the calcium!’ Tulane virus takes over cellular calcium signaling to replicate

November 12, 2019November 13, 2019gastrointestinal virus, human norovirus, NS1-2, Research, rotavirus, Tulane virus, viroporin

Some gastrointestinal viruses need calcium. They need calcium ions to carry out several essential aspects of viral life, such as entry into host cells, genome

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Still image to accompany July 2019's Video of the Month (Hyser lab) Cells expressing a fluorescent calcium sensor (green) were infected with rotavirus, a virus that causes acute gastroenteritis. The rotavirus-infected cells (pink) trigger an intercellular calcium wave that increases calcium in surrounding uninfected cells. (Scale bar = 100 μm; courtesy of the Hyser lab).
From The Labs 

Video of the Month: A calcium storm

July 2, 2019July 24, 2019calcium indicator, gastroenteritis, Research, rotavirus, video

From the Labs opens July 2019 with a Video of the Month, showing the calcium ‘storm’ rotavirus triggers in infected cells. Calcium signaling in rotavirus

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From The Labs 

‘Can you hear me, now?’ A new strategy ‘raises the volume’ of hard-to-detect gut-body communication

June 27, 2019June 27, 2019enteroendocrine cells, enteroids, gut-body communication, microbiome, neurogenin-3, Norovirus, Research, rotavirus, serotonin

Throughout the gastrointestinal tract there are specialized hormone-producing cells called enteroendocrine cells and, although they comprise only a small population of the total cells, they

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From The Labs 

Image of the Month: Assembling a rotavirus factory

January 3, 2019January 3, 2019CK1 alpha, NSP2, phsophorylation, Research, rotavirus, rotavirus factory

Making new viruses requires assembling intracellular replication factories via a complex, little known process that involves both viral and cellular components. New insights into this

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From The Labs 

Baylor College of Medicine faculty members elected fellows of the National Academy of Inventors

December 18, 2018December 18, 2018Alzheimer's, Cancer, NAI, National Academy of Inventors, Norovirus, Research, Rett Syndrome, rotavirus

Drs. Mary K. Estes, Bert O’Malley and Huda Zoghbi of Baylor College of Medicine were three of the 148 renowned academic inventors named fellows of

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From the Labs Image of the Month

From The Labs Image of the Month From the Labs: A selection of From the Labs Images of the Month on display in the A Hallway at Main Baylor.

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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