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From The Labs

PKMYT1, a potential ‘Achilles heel’ of treatment resistant ER+ breast cancers with the poorest prognosis

May 28, 2024 Breast Cancer,  CDK4/6,  kinases,  KIPA,  p53,  PKMYT1,  Research,  treatment resistant

The challenge was to identify the kinase among hundreds of kinases in these treatment-resistant tumors that would help turn the tide in the fight against this cancer.

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From The Labs

2024 Michael E. DeBakey Excellence in Research Awards

May 23, 2024 DeBakey Research Awards,  Research

The Michael E. DeBakey Excellence in Research Awards recognize our faculty’s outstanding published scientific contributions to clinical and basic science research over the past three years.

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nci-ewing-sarcoma
From The Labs

CAR T cell therapy targeting HER2 antigen shows promise against advanced sarcoma in phase I clinical trial

May 21, 2024 CARTcell therapy,  HEROS clinical trial,  Research,  sarcoma

The HEROS 2.0 trial showed that this therapeutic approach is safe and is associated with clinical benefit.

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From The Labs

ERR-gamma marks the road leading to acid-producing cells

May 16, 2024 acid-producing cells,  ERR-g,  indigestion,  parietal cells,  Research,  stem cells,  stomach cancer

The findings open new opportunities to regulate the function of acid-producing cells in the stomach in different disease settings.

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From The Labs

How gliding mammals happened

May 14, 2024 Emx2,  enhancers,  Evolution,  gliding mammals,  Research,  sugar glider

Comparing genomic sequences of gliding marsupials and non-gliding relatives revealed differences crucial to the development of gliding.

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A doctor holding a tablet computer
From The Labs

Using AI to improve diagnosis of rare genetic disorders

May 9, 2024 AI,  artificial intelligence,  exome reanalysis,  genetic diagnosis,  MARRVEL,  Mendelian disorders,  Rare Diseases,  Research

AIM narrows the differential genetic diagnoses down to a few genes and can potentially guide the discovery of previously unknown disorders.

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Colorized scanning electron micrograph of Vero cells heavily infected with SARS-COV-2 virus particles.
From The Labs

A mechanism influencing the generation of new COVID variants

May 7, 2024 COVID evolution,  COVID mutation,  COVID variants,  Research,  tARC-seq,  template switching

SARS-CoV-2 takes advantage of powerful biological mechanisms that allow it to evolve quickly, generating variants to adapt to and persevere in human populations.

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Six colorful images resembling human faces
From The Labs

Image of the Month: Faces of embryo development

May 2, 2024 embryo development,  Image of the month,  inner ear,  Research,  vertebrate head development

Sometimes, research inspires scientists like Dr. Ankita Thawani to dig into their artistic side to create renditions of their findings.

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From The Labs

Uncovering the secret of long-lived stem cells

April 30, 2024 Aging,  chaperone,  cyclophilin A,  hematopoietic stem cells,  intrinsically disordered proteins,  PPIA,  Research

A protein produced in large amounts in HSCs is key for these cells to retain their regenerative potential and avert the effects of aging.

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A pair of hands working with research samples.
From The Labs

Research method finds new use in diagnosis of genetic disorders

April 25, 2024 genetic diagnosis,  Rare Diseases,  Research,  RNA sequencing,  transdifferentiation

This new testing method represents a paradigm shift in laboratory genetics, moving from the traditional DNA-centric approach to one focusing on the patient’s cells.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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