Defective serotonin 2C receptors lead to memory deficits in mice and humans
The findings not only provide new insight into the factors regulating healthy memory but also in conditions associated with memory loss, like Alzheimer’s disease.
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Research
Image of the Month: The wooly mammoth emerges from the past
Researchers have peered into the chromosomes of the wooly mammoth, a magnificent creature that has been extinct for nearly 4,000 years.
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Cells with IFITM5 mutation get caught in a loop leading to osteogenesis imperfecta type V
These findings not only inform on the mechanism of OI type V, they also facilitate the development of future therapies for this condition.
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Study opens new opportunities to develop cancer treatments
The team integrated proteogenomic datasets of more than 1,000 tissue samples spanning 10 cancer types to illuminate protein targets for cancer therapy.
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CAR T cell therapy for pediatric brain cancer warrants further study
This study shows that this therapy can effectively get to the tumor, and the addition of C7R safely augments antitumor activity.
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A promising approach to develop a birth control pill for men
The novel strategy is sperm-specific, has minimal safety concerns and the effects are reversible in animal models.
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hnRNPM, a guardian of the integrity of cellular protein synthesis
A connection with cancer cells suggests that hnRNPM may hold clinical promise.
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Image of the Month: Defective sperm
Alterations in normal sperm shape and motility led to infertility in an animal model and inspired work to develop a reversible birth control pill for men.
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Baylor College of Medicine researchers set the foundation for novel rare disease treatment
The story behind the discovery that led to the novel treatment revealed that scientific breakthroughs can sometimes happen in unexpected ways.
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PKMYT1, a potential ‘Achilles heel’ of treatment resistant ER+ breast cancers with the poorest prognosis
The challenge was to identify the kinase among hundreds of kinases in these treatment-resistant tumors that would help turn the tide in the fight against this cancer.
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