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From The Labs

New research moves novel gene therapy for heart failure closer to the clinic

July 20, 2021 cardiomyocytes,  gene therapy,  heart attack,  heart failure,  heart repair,  Hippo pathway,  Research

Knocking down the Hippo signaling pathway in pig cardiomyocytes after a heart attack, resulted in heart tissue renewal and improved function.

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Cardiofibroblasts Martin FTL
From The Labs

Image of the Month: cardiac fibroblasts

November 5, 2019 cardiac fibroblasts,  heart attack,  heart failure,  Hippo pathway,  LATS 1/2,  Research

This Image of the Month features the cardiac fibroblast, a cell that is central to heart failure, the leading cause of mortality in the U.S.

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From The Labs

What the Hippo pathway in cardiac fibroblasts reveals about heart function

October 15, 2019 cardiac fibroblasts,  cardiomyocytes,  heart attack,  heart regeneration,  Hippo pathway,  Research,  YAP

Heart failure remains the leading cause of mortality in the U.S. During a heart attack, blood stops flowing into the heart. Without oxygen, part of

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From The Labs

The Hippo pathway: tailor of the developing heart

July 5, 2018 blood vessels,  heart development,  heart growth,  Hippo pathway,  Research,  single cell transcriptomics

The Hippo pathway is an inhibitor of adult heart regeneration; if you take the Hippo pathway away, then the heart can regenerate. But, can the

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From The Labs

Tapping on the healing capacity of the heart

January 5, 2018 Heart disease and regeneration,  heart failure,  Hippo pathway,  injured heart,  mouse model,  regeneration

If your skin is injured, it can heal itself. If you lose blood, your body makes more. If a lobe is removed from a mouse

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From The Labs

Together, DAG1 and Yap ‘hit the brakes’ on heart cell proliferation

September 15, 2017 cardiomyocyte,  DAG1,  heart cell proliferation,  heart disease,  Hippo pathway,  muscular dystrophy,  YAP

Although both are known to play a role in cardiac function and previous work had hinted that they might interact with each other, it was

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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