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From The Labs

Black History Month Spotlight: Interview with Dr. Roy Sillitoe

February 9, 2021 Black History Month,  deep brain stimulation,  Neurodegeneration,  Research,  Tremor

Dr. Sillitoe shared his approach of ‘mixing the sciences’ to unravel the causes of brain diseases and something few people know about him.

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From The Labs

Using proteogenomics to improve the treatment of squamous cell carcinoma

February 4, 2021 precision cancer treatment,  proteogenomics,  Research,  squamous cell carcinoma

Integrating proteogenomics data of squamous cell carcinoma provides insights into genomic defects with implications for potential treatments.

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From The Labs

Image of the Month: Hues of HeLa

February 1, 2021 GI infection,  HeLa,  Image competition,  Image of the month,  Research

Our own Dr. Kristen Engevik is the winner of “CELL-ebrating HeLa” image competition with the image “Hues of HeLa.”

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From The Labs

Light-activated genes illuminate the role of gut microbes in longevity

January 28, 2021 Aging,  C. elegans,  colanic acid,  Longevity,  microbiome,  optogenetics,  Research

Optogenetics, a method that uses light to regulate gene expression, can control gut bacterial metabolism to promote longevity.

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From The Labs

Engineering meets biology to design innovative multifunctional surgical Biomesh

January 27, 2021 3D printed surgical Biomesh,  hernia repair,  inflammation,  Research,  X-PVA

An innovative, 3D printed surgical Biomesh not only provides mechanical support but also plays a physiological role of reducing the inflammatory response that causes significant clinical problems.

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From The Labs

Connecting the dots between lactating mother’s diet, milk composition, microbiome and benefits of mother’s milk

January 26, 2021 Breastfeeding,  diet,  HMO,  metabolic health,  milk microbiome,  Research

This study reports the first evidence that the mother’s diet while breastfeeding can shape the profile of HMOs, a type of food for microbes, which in turn modifies the functional abilities of the milk microbiome.

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From The Labs

Waking up sleeping beauty – persistent IFN-gamma awakens and activates stem cells via BST2

January 21, 2021 blood stem cells,  bone marrow transplant,  BST2,  E-selectin,  homing,  IFN,  Infectious diseases,  Research

The researchers show that persistent IFNγ mediates the exhaustion of blood stem cells via BST2 expression.

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From The Labs

Study of spliceosome-targeting cancer therapies reveals an overlooked role of mis-spliced RNAs themselves

January 19, 2021 apoptosis,  cancer treatment,  Immunotherapy,  Research,  RNA splicing,  Spliceosome-targeting therapies,  triple-negative breast cancer

Endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection.

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From The Labs

BICRA gene variants linked to a neurodevelopmental disorder

January 14, 2021 BICRA gene,  Coffin-Siris syndrome,  fruit fly,  neurodevelopmental disease,  neurodevelopmental disorder,  Research,  zebra fish

Genetic testing of an undiagnosed condition triggered a study that linked the BICRA to a neurodevelopmental disorder.

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From The Labs

‘Rule-breakers’ help identify novel gene variants that modify risk of late-onset Alzheimer’s disease

January 12, 2021 ADSP,  APOE,  fruit fly,  genetic risk,  Late-onset Alzheimer’s disease,  Research

Using novel methodologies, researchers identified 216 new gene variants, many previously not suspected to play a role in Alzheimer’s disease.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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