DM1 Archives - Baylor College of Medicine Blog Network

Unexpected findings provide a deeper understanding of Myotonic Dystrophy Type 1

Oct 29, 2024 DM1, DMPK, heart problems, muscle wasting, Research, SCN5A

While the Baylor team was testing a strategy to improve heart defects associated with DM1, they uncovered an unexpected new insight into the condition.

From The Labs

Focused on the Heart — Novel mouse model of myotonic dystrophy displays reversible cardiac disease features of the condition

Apr 27, 2021 alternative splicing, arrhythmias, cardiac function, DM1, DMPK gene, mouse model, myotonic dystrophy, Research

This model of DM1 allows researchers to both focus on cardiac mechanisms of the disease and to expand therapeutics to target the heart.

From The Labs

Nuclear, not cytoplasmic CELF1, has a stronger role in muscle wasting

Dec 29, 2020 alternative splicing, CELF1 and MBNL proteins, DM1, DMPK gene, muscle wasting, myotonic dystrophy, Research

This work is the first to show that the response of muscle to CELF1 overexpression depends on the cellular localization of the protein.

From The Labs

There is more going on in DM1 than just alternative splicing

Jun 26, 2018 alternative splicing, AMPK-alpha, DM1, DMPK gene, myotonic dystrophy, PDGFR-beta, Research

Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy that affects multiple organ systems. People with this condition develop progressive muscle wasting

From The Labs

Image of the Month: What causes myotonic dystrophy, type1

Sep 5, 2017 alternative splicing, CELF1 and MBNL proteins, CTG repeat, CUGexp, DM1, DMPK gene, MEF2 transcription factor, muscular dystrophy, myotonic dystrophy, RNA splicing

Myotonic dystrophy, type 1 (DM1) is the second most common cause of muscular dystrophy and numerous other muscle disorders that affect tens of thousands of