Restoring heart function in Myotonic Dystrophy Type 1
The findings are relevant to current therapeutic approaches for DM1 that are based on increasing MBNL protein.
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Unexpected findings provide a deeper understanding of Myotonic Dystrophy Type 1
While the Baylor team was testing a strategy to improve heart defects associated with DM1, they uncovered an unexpected new insight into the condition.
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Focused on the Heart — Novel mouse model of myotonic dystrophy displays reversible cardiac disease features of the condition
This model of DM1 allows researchers to both focus on cardiac mechanisms of the disease and to expand therapeutics to target the heart.
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Nuclear, not cytoplasmic CELF1, has a stronger role in muscle wasting
This work is the first to show that the response of muscle to CELF1 overexpression depends on the cellular localization of the protein.
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There is more going on in DM1 than just alternative splicing
Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy that affects multiple organ systems. People with this condition develop progressive muscle wasting
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Image of the Month: What causes myotonic dystrophy, type1
Myotonic dystrophy, type 1 (DM1) is the second most common cause of muscular dystrophy and numerous other muscle disorders that affect tens of thousands of
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