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From The Labs

AKAP8 and the delicate balance between normal and metastatic states

March 12, 2020 AKAP8,  alternative splicing,  Breast Cancer,  CD44,  CLSTN1,  metastatis,  Research

A protein naturally produced in the body has been found to suppress breast cancer metastasis in animal models of human tumors. “Our laboratory investigates cellular

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From The Labs

CD44 variants prompt different cancer cell behaviors

February 21, 2019 alternative splicing,  Breast Cancer,  cancer heterogeneity,  cancer plasticity,  CD44,  Metastasis,  Research,  resistance to treatment

Imagine fighting enemies that differ in their susceptibility to the weapon you are using against them. Some will perish, but others will survive the attack

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From The Labs

G-quadruplex helps breast cancer survive

February 15, 2018 alternative splicing,  Breast Cancer,  CD44,  G-quadruplex

For breast cancer, expressing the protein CD44s, instead of CD44v, has a survival advantage. And one of the goals of Dr. Chonghui Cheng lab  is to

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From The Labs

Image of the Month: Mechanisms of cancer survival

August 1, 2017 alternative splicing,  cancer survival,  CD44,  EGFR signaling,  Image of the month,  PI3K/Akt signaling

  Among other studies, the  lab of Dr. Chonghiu Cheng is pioneering research projects to better undertsand the role alternative splicing plays in cancer. “We have been

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From The Labs

CD44s, not CD44v, contributes to cancer survival

July 25, 2017 Akt pathway,  alternative splicing,  cancer survival,  CD44,  EGFR signaling

Cells may stray away from their normal function in a number of ways. For example, it’s been known for some time that in a number

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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