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From The Labs

New research moves novel gene therapy for heart failure closer to the clinic

July 20, 2021 cardiomyocytes,  gene therapy,  heart attack,  heart failure,  heart repair,  Hippo pathway,  Research

Knocking down the Hippo signaling pathway in pig cardiomyocytes after a heart attack, resulted in heart tissue renewal and improved function.

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From The Labs

What the Hippo pathway in cardiac fibroblasts reveals about heart function

October 15, 2019 cardiac fibroblasts,  cardiomyocytes,  heart attack,  heart regeneration,  Hippo pathway,  Research,  YAP

Heart failure remains the leading cause of mortality in the U.S. During a heart attack, blood stops flowing into the heart. Without oxygen, part of

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From The Labs

Preventing sudden cardiac death with genome editing

October 30, 2018 cardiomyocytes,  catecholaminergic polymorphic ventricular tachycardia,  CRISPR/Cas9,  inherited cardiac arrhythmia disorders,  R176Q,  Research,  RyR2,  sudden cardiac death

Each year, at least 3 million people worldwide die of sudden cardiac death. In the U.S., this number reaches up to 450,000 people. Although sudden

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From The Labs

Eliminating p63 gene could convert scar tissue into heart muscle

May 29, 2018 cardiomyocytes,  cellular reprogramming,  fibroblasts,  heart attack,  p63,  Research

After a heart attack, the parts of the heart muscle that die do not regenerate into new heart tissue; instead, they are replaced by scar

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From The Labs

How Gata4 helps mend a broken heart

August 14, 2017 Cardiac regeneration,  cardiomyocytes,  fibroblasts,  fibrosis,  Gata4,  heart attack,  heart failure,  scar tissue,  tissue reprograming

During a heart attack, blood stops flowing into the heart; starved for oxygen, part of the heart muscle dies. The heart muscle does not regenerate;

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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