Crystal structure of PKGI suggests a new activation mechanism
By Ana María Rodríguez, Ph.D. Kinases form a large family of proteins that seem to be involved in nearly every aspect of cell life. Faulty
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Biochemistry
Evolution meets biochemistry to better understand how dopamine receptors work
When proteins fail at doing their job, disease usually follows. To perform their job, proteins need to maintain a particular structure and specific motions,
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One atom can make a difference: Hydrogen-bonding pairing helps design better drugs to neutralize gut bacterial infections
IP6, the natural inhibitor or ligand of Clostridium difficile’s toxin, binds weakly to the toxin. This results in the toxin remaining active (center figure). Changing
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Social amoeba cast wide, lethal DNA nets to kill invading bacteria
By Ruth SoRelle, M.P.H. The amoeba Dictyostelium discoideum begins as a soil-dwelling single cell organism. When stressed, many individual cells coalesce to form first a slug
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Prized speakers, including Nobel Laureate, to speak at BCM March 7
For an established scientist like myself with a 40-plus year career studying biochemistry and genetics, there is no greater enjoyment than learning new science. That’s why
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