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From The Labs

Rotavirus protein NSP4 manipulates gastrointestinal disease severity

February 6, 2025 calcium waves,  gastroenteritis,  NSP4,  Research,  rotavirus

The findings suggest that regulating NSP4 could lead to new strategies to prevent or treat rotavirus infections.

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From The Labs

Discovering replication hubs of human norovirus

January 30, 2025 gastroenteritis,  GII.4,  Norovirus,  positive-strand RNA virus,  replication factories,  Research,  RNA polymerase

The findings offer potential new targets for antivirals to treat this serious threat to children and immunocompromised patients.

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From The Labs

Researchers are making strides in the fight against gastroenteritis

March 7, 2023 cellular injury,  CLIC pathway,  gastroenteritis,  GII4,  human norovirus entry mechanism,  Norovirus,  Research

The findings provide insight into the viral infection process, highlighting unique pathways and targets for developing effective therapeutics.

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From The Labs

Artificial intelligence reveals a never-before described 3D structure in rotavirus spike protein

June 9, 2022 ALphaFold2,  gastroenteritis,  N-acetyllactosamine,  Research,  rotavirus,  spike protein,  VP8*,  X-Ray crystallography

The findings are an example of how viruses can evolve by incorporating structurally distinct modules with similar functionality.

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From The Labs

Not all human norovirus strains are created equal, in their sensitivity to interferon

September 22, 2020 gastroenteritis,  human intestinal enteroids,  human norovirus,  Interferon,  Research

A new study reveals that human norovirus strains differ in sensitivity to the body’s first line of defense.

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Still image to accompany July 2019's Video of the Month (Hyser lab) Cells expressing a fluorescent calcium sensor (green) were infected with rotavirus, a virus that causes acute gastroenteritis. The rotavirus-infected cells (pink) trigger an intercellular calcium wave that increases calcium in surrounding uninfected cells. (Scale bar = 100 μm; courtesy of the Hyser lab).
From The Labs

Video of the Month: A calcium storm

July 2, 2019 calcium indicator,  gastroenteritis,  Research,  rotavirus,  video

From the Labs opens July 2019 with a Video of the Month, showing the calcium ‘storm’ rotavirus triggers in infected cells. Calcium signaling in rotavirus

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From The Labs

Image of the Month: Repairing rotavirus-damaged intestinal cells

March 1, 2018 gastroenteritis,  intestinal stem cells,  Mary Estes,  Norovirus,  Research,  rotavirus

When rotavirus infects and damages intestinal cells, the small intestine fails to absorb nutrients and diarrhea develops. Rotaviruses and noroviruses are the major cause of

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From The Labs

From the Labs to Commercialization: the Estes lab and ImmuCell Success Story

February 6, 2018 Baylor Licensing Group,  calf gastroenteritis,  gastroenteritis,  ImmuCell,  Mary Estes lab,  rotavirus,  rotavirus vaccine,  scours,  virus-like particles

Research discoveries at Baylor College of Medicine can potentially reach the point where they evolve into practical applications that improve the quality of life. After

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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