Video of the Month: A calcium storm

From the Labs opens July 2019 with a Video of the Month, showing the calcium ‘storm’ rotavirus triggers in infected cells.

Calcium signaling in rotavirus infection

Cells expressing a fluorescent calcium sensor (green) were infected with rotavirus, a virus that causes acute gastroenteritis. The rotavirus-infected cells (pink) trigger an intercellular calcium wave that increases calcium in surrounding uninfected cells.  (scale bar = 100 μm; video courtesy of the Hyser lab).

 

 

The laboratory of Dr. Joseph Hyser is dedicated to investigating a number of aspects related to the mechanisms of action of pathogens such as rotavirus. The lab’s specific areas of interest include:

  • Enteric virus calcium channel blockers
  • Exploitation of host calcium signaling pathways by microbes
  • Characterization of viral Ion channels (viroporins)
  • Engineering of human intestinal enteroids

Read one of Hyser’s most recent publications about how they ‘raised the volume’ of hard-to-detect gut-body communication in the journal Cellular and Molecular Gastroenterology and Hepatology and in From the Labs.

 

Dr. Joseph M. Hyser

 

 

Dr. Joseph Hyser is an assistant professor of virology and microbiology and a member of the Alkek Center for Metagenomics and Microbiome Research and the Dan L Duncan Comprehensive Cancer Center at Baylor College of Medicine.

 

 

 

 

 

By Ana María Rodríguez, Ph.D.

 

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