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From The Labs

How MAGE-A4 helps tumors evade immune responses crucial for their elimination

February 20, 2025 immune response evasion,  lung cancer,  MAGE-A4,  non-small cell lung cancer,  plasma cells,  PTEN,  Research

The next step could include human clinical trials to test potential therapeutic avenues to restore the ability to fight the tumor.

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From The Labs

Rare chromosome reshuffling leads to severe complex form of epilepsy

February 18, 2025 5q14.3 microdeletion syndrome,  chromosome reshuffling,  chromothripsis,  clinical diagnosis,  developmental epileptic encephalopathy,  epilepsy,  Lennox-Gastaut syndrome,  Research

Although it’s more commonly found in cancer, chromosome reshuffling is increasingly identified in neurodevelopmental disorders.

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A doctor, seen from the neck down, writing on paper while talking to another person.
From The Labs

Uncovering unique features of early onset colorectal cancer in racial and ethnic minorities

February 13, 2025 Colorectal Cancer,  DNA methylation,  early onset colon cancer,  epigenetics,  racial and ethnic minorities,  Research

The findings bring hope and direction to better understand this emerging condition and support continuing these studies.

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A person wearing headphones pumping a fist happily.
From The Labs

Hear this – researchers are mapping the cells that tune in to sound

February 11, 2025 auditory brainstem,  auditory disorders,  cochlear nucleus,  hearing,  Research,  sound

The findings challenge long-standing principles of hearing processing in the brain and offer fresh avenues for therapeutic exploration.

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From The Labs

Rotavirus protein NSP4 manipulates gastrointestinal disease severity

February 6, 2025 calcium waves,  gastroenteritis,  NSP4,  Research,  rotavirus

The findings suggest that regulating NSP4 could lead to new strategies to prevent or treat rotavirus infections.

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From The Labs

Sprinter and marathoner CAR T cells reveal their distinct cancer-killing behavior

February 4, 2025 cancer treatment,  CAR T cell,  Research,  solid tumors

The study lays a foundation for designing CAR molecules that maximize antitumor activity beyond B cell malignancies.

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From The Labs

Discovering replication hubs of human norovirus

January 30, 2025 gastroenteritis,  GII.4,  Norovirus,  positive-strand RNA virus,  replication factories,  Research,  RNA polymerase

The findings offer potential new targets for antivirals to treat this serious threat to children and immunocompromised patients.

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Pre- and post-infusion three-dimensional imaging shows that infused GPC3 CAR T cells induce significant antitumor responses in patients.
From The Labs

From bench to bedside and back: CAR T cells armed with IL-15 show promise in treating solid cancers

January 28, 2025 cancer treatment,  CAR T cells,  Clinical Trials,  IL-15,  Research,  solid tumors

Researchers relate their journey to finding a promising method to address CAR T cell challenges in treating solid tumors.

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A person holding a knife and chopping slices of cheese to go along with nuts, breads and other finger foods already placed on serving platters.
From The Labs

Feeling hungry? Beginning a meal starts in the brain

January 23, 2025 dopamine,  GABA,  hunger,  meal initiation,  Research

This study reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake.

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From The Labs

Top five most viewed Images of the Month in 2024

January 17, 2025 Image of the month,  most popular,  Research,  top 5

Our viewers selected these Images of the Month as the most popular of 2024.

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From the Labs: Image of the Month

Blood vessels (magenta) intertwined with metastatic medulloblastoma tumor cells (green) nestled within the protective layers that surround the mouse spinal cord. From the Labs: a closer look at metastatic medulloblastoma

Healthy Habits: A DOC-umentary Series

https://www.youtube.com/watch?v=SlNiMWHUhbc

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