Ataxia mutant protein uses distinct partners to drive toxicity in different brain cells
This study proposes a mechanism for the differential vulnerability of brain cells and regions to toxic mutant proteins.
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SCA1
Regulating gene regulatory regions offers a novel mechanism to control ATXN1 levels
Researchers identified a novel mechanism that regulates ATXN1 levels and reduces SCA1 symptoms in animal model.
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Ataxin-1: One gene, two different neurodegenerative diseases
Certain variants of the ataxin-1 gene cause a rare neurodegenerative disease called spinocerebellar ataxia type 1 (SCA1). Years ago, the lab of Dr. Huda Zoghbi
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When protein regulators go awry, neurological disease may follow
Scientists are expanding their horizons in their search for disease-causing genes. Consider for instance a neurological condition called spinocerebellar ataxia type 1 (SCA1), a disease
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