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Image of the Month: Brain of a mouse model of Huntington’s Disease
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ataxia

From The Labs

Fine-tuning deep brain stimulation plus exercise restore movement in ataxia

April 6, 2021April 6, 2021 Ana Rodríguez 0 Comments ataxia, deep brain stimulation, Purkinje cells, Research

A precise combination of DBS and exercise rescued and maintained limb coordination and stepping in mice without further stimulation.

From The Labs

Regulating gene regulatory regions offers a novel mechanism to control ATXN1 levels

August 27, 2020August 27, 2020 Ana Rodríguez 0 Comments ataxia, ATXN1, balance problems, gene regulation, microRNA, movement problems, Research, SCA1

Researchers identified a novel mechanism that regulates ATXN1 levels and reduces SCA1 symptoms in animal model.

From The Labs

Image of the Month: SCA1-like neurodegeneration

May 1, 2018May 1, 2018 Ana Rodríguez 0 Comments ataxia, mouse model, Neurodegeneration, pumilio, Purkinje cells, Research, spinocerebellar ataxia type 1

In a mouse model of spinocerebellar ataxia type 1 (SCA1), mice carrying mutant Pumilio1 genes develop progressive motor deficits and cerebellar degeneration. Studies conducted by the

From the Labs features an image showing the striatum in the brain of a mouse model of Huntington’s Disease. Image courtesy of Dr. Juan Botas/eLife, 2021.