Losing neurofibromin is good news for breast cancer
It is well known that neurofibromin (NF1), a tumor suppressor produced by the NF1 gene, keeps cancer growth in check by repressing the activity of
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estrogen receptor-positive
Estrogen receptor can affect resistance to endocrine therapy and metastasis in breast cancer
Resistance to therapy is common in estrogen receptor positive (ER+) breast cancer, the most common type of breast cancer, and eventual development of metastatic disease
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How breast cancer can become resistant to hormone therapy
Despite the overall success of hormone therapy, breast cancer tumors in patients with metastatic disease often fail to respond. One new mechanism that can explain
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