From the Labs celebrates Heart Month with an image of a transparent mouse heart.
The blood vessels are labeled with perfused lectin and processed with tissue clearing protocol EZ Clear to render the whole heart optically transparent for imaging. The cleared mouse heart was whole mount imaged on the Zeiss Lightsheet Z.1 fluorescence microscope in the Optical Imaging and Vital Microscopy Core at Baylor College of Medicine. Lectin-labeled vasculature was color-coded through imaging depth and projected across 1.3 mm of the acquired volume. Image Credit: Chih-Wei Logan Hsu.
Learn more about the EZ Clear process that enables easier and faster 3D imaging of entire intact tissues or even entire organs, and see more images and videos in the paper published in eLife. Read an interview with the authors in From the Labs.
Dr. Chih-Wei Logan Hsu is assistant professor of integrative physiology and of education, innovation, and technology as well as co-director of the Optical Imaging and Vital Microscopy Core at Baylor College of Medicine.