DNA repair Archives - Baylor College of Medicine Blog Network

A new mechanism of cisplatin resistance in cancer, and how to reverse it

April 22, 2021 ACTL6A, cancer resistance to therapy, cisplatin, DNA repair, epigenetic chromatin remodeling, panobinostat, Research

ACLT6A overexpression confers cancer cells resistance to cisplatin, and researchers found a way to reverse it.

From The Labs

Identifying rare genetic variants that increase risk for lung cancer

March 18, 2021 ATM, DNA damage, DNA repair, exome sequencing, genomic instability, lung cancer, MLNR, Pomc, Research

Exome sequencing identified new variants that lead to higher levels of DNA damage, which increases the susceptibility for multiple cancers.

From The Labs

Exceptional responders reveal cancer’s Achilles heel

December 15, 2020 Cancer, cancer microenvironment, DNA repair, exceptional responders, Research

Genome sequencing analysis of biopsied tumors points at genetic explanations for exceptional responses to therapeutics.

From The Labs

When DNA is caught at the break

January 15, 2019 Cancer, DNA fragments, DNA repair, Dna2, immune system, Research

Cells have in place a number of mechanisms to protect the integrity of the genome, including processes that repair mistakes that may occur during DNA

From The Labs

What matters the most to cells

December 14, 2017 DNA biology, DNA repair, DNA transcription, E. Coli, eXOnucleases sequencing, fidelity of transcription, GreA, protein synthesis, RNA

“If you asked a group of scientists which is more important for a cell, maintaining the integrity of its DNA containing all of the organism’s

From The Labs

“Freeze-frame” synthetic proteins capture DNA events leading to cancer

January 11, 2017 Cancer, cancer evolution, DNA repair, E. Coli, Freeze-frames proteins, Genetics

Cancer scientists have focused on identifying signature genetic changes present in cancerous cells and understanding how these changes lead to cancer. Although this approach has