Congratulations to the transparent heart, the most viewed image of the month of 2023!
The cleared mouse heart was whole mount imaged on the Zeiss Lightsheet Z.1 fluorescence microscope in the Optical Imaging and Vital Microscopy Core at Baylor College of Medicine. The blood vessels are labeled with perfused lectin and processed with tissue clearing protocol EZ Clear to render the whole heart optically transparent for imaging. Lectin-labeled vasculature was color-coded through imaging depth and projected across 1.3 mm of the acquired volume.
Dr. Chih-Wei Logan Hsu, assistant professor of integrative physiology and of education, innovation, and technology as well as co-director of the Optical Imaging and Vital Microscopy Core at Baylor College of Medicine, created this image.
Learn more about the EZ Clear process that enables easier and faster 3D imaging of entire intact tissues or even entire organs, and see more images and videos in the paper published in eLife. Read an interview with the authors in From the Labs.
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