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Hispanic Heritage Spotlight: Interview with Dr. Juan Botas

October 29, 2020 Alzheimer's, Espana, Hispanic Heritage, Huntington’s, neurodegenerative diseases, Parkinson's, Rare Diseases, Research

Dr. Juan Botas shared his challenging beginnings, his passion for neuroscience and how he is bringing science to a general audience.

Close up of neurons from the brain cortex of a mouse with Huntington's disease.

From The Labs

Image of the Month: Neurons in a Huntington’s brain

October 14, 2025 Huntington’s disease, Image of the month, Neurological disorders, Research

Dr. Juan Botas’s lab integrates laboratory, animal model and computational approaches to gain a deeper understanding of Huntington’s disease and other neurological disorders.

From The Labs

A combined computational and experimental approach uncovered promising genetic players in Alzheimer’s disease

May 8, 2025 Alzheimer's Disease, Alzheimer's genetic risk factors, computational model, fruit fly model, human neural progenitor cells, MTCH2, Research

This study provides solutions to the pressing need to identify factors that influence Alzheimer’s disease risk or resistance while offering a means explore potential biological markers and therapeutic targets.

From The Labs

Innovative machine-learning program reveals genes responsible for sex-specific differences in Alzheimer’s disease

June 20, 2023 Alzheimer's Disease, Alzheimer's genes, EAML, Research, sex differences, small samples

This approach, called Evolutionary Action Machine Learning, enables researchers to probe smaller cohorts with greater accuracy.

From The Labs

The Most Viewed Image of the Month in 2021

December 3, 2021 animal model, Brain, Huntington’s disease, Research

Brain of a mouse model of Huntington’s disease.

From The Labs

Glial cells help mitigate neurological damage in Huntington’s disease

June 24, 2021 brain protection, fruit fly model, glia cells, Huntington’s disease, mouse model, Research, synapse genes

Research with human samples and mouse and fruit fly models opens a window into the brain’s protective responses in Huntington’s disease.

From The Labs

Image of the Month: Brain of a mouse model of Huntington’s Disease

May 4, 2021 Alzheimer's, Huntington disease, Image of the month, mouse model, Parkinson disease, Research

This confocal microscopy image shows a section of the brain of a mouse model of Huntington’s disease, with the astrocytes in green and cell nuclei in blue.

From The Labs

‘Rule-breakers’ help identify novel gene variants that modify risk of late-onset Alzheimer’s disease

January 12, 2021 ADSP, APOE, fruit fly, genetic risk, Late-onset Alzheimer’s disease, Research

Using novel methodologies, researchers identified 216 new gene variants, many previously not suspected to play a role in Alzheimer’s disease.

From The Labs

Sorting out what drives Huntington’s disease

July 12, 2018 fruit fly, high-throughput, huntingtin, Huntington’s disease, neurological disease, Research

Neurological diseases are typically associated with a multitude of molecular changes. But out of thousands of changes in gene expression, which ones are actually driving

From The Labs

A new approach to potentially treat Huntington’s disease

February 13, 2018 autophagy, huntingtin, Huntington’s disease, lysosome storage disorder, NCT-504, PIP4Kgamma, PIP4Kγ

In Huntington’s disease, a single faulty gene called huntingtin causes a progressive breakdown of nerve cells in the brain and severe physical and neurological damage